Identification of a High-Level MET Amplification in CTCs and cfTNA of an ALK-Positive NSCLC Patient Developing Evasive Resistance to Crizotinib

被引：21

作者：

Berger, Lars-Arne ^{[1
]}

Janning, Melanie ^{[1
,2
]}

Velthaus, Janna-Lisa ^{[1
,2
]}

Ben-Batalla, Isabel ^{[1
,2
]}

Schatz, Stefanie ^{[3
]}

Falk, Markus ^{[3
]}

Iglauer, Peter ^{[4
]}

Simon, Ronald ^{[4
]}

Cao, Ru ^{[5
]}

Forcato, Claudio ^{[6
]}

Manaresi, Nicolo ^{[6
]}

Bramlett, Kelli ^{[5
]}

Buson, Genny ^{[6
]}

Hanssen, Annkathrin ^{[2
]}

Tiemann, Markus ^{[3
]}

Sauter, Guido ^{[4
]}

Bokemeyer, Carsten ^{[1
]}

Riethdorf, Sabine ^{[2
]}

Reck, Martin ^{[7
]}

Pantel, Klaus ^{[2
]}

Wikman, Harriet ^{[2
]}

Loges, Sonja ^{[1
,2
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Oncol Hematol & Bone Marrow Transplantat, Sect Pneumol, Hubertus Wald Univ Comprehens Canc Ctr Hamburg, Martinistr 52, D-20246 Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Ctr Med Expt, Dept Tumor Biol, Hamburg, Germany

[3] Inst Hematopathol Hamburg HpH, Hamburg, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Inst Pathol, Hamburg, Germany

[5] Thermo Fisher Sci, Austin, TX USA

[6] Menarini Silicon Biosyst, Bologna, Italy

[7] German Ctr Lung Res, Airway Res Ctr North, Lung Clin Grosshansdorf, Grosshansdorf, Germany

来源：

JOURNAL OF THORACIC ONCOLOGY | 2018年 / 13卷 / 12期

关键词：

D O I：

10.1016/j.jtho.2018.08.2025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：E243 / E246

页数：4

共 5 条

[1] Liquid Biopsies, What We Do Not Know (Yet) [J].

Bardelli, Alberto ;

Pantel, Klaus .

CANCER CELL, 2017, 31 (02) :172-179

[2] Crizotinib Can Overcome Acquired Resistance to CH5424802 [J].

Gouji, Toyokawa ;

Takashi, Seto ;

Mitsuhiro, Takenoyama ;

Yukito, Ichinose .

JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (03) :E27-E28

[3] Activated MET acts as a salvage signal after treatment with alectinib, a selective ALK inhibitor, in ALK-positive non-small cell lung cancer [J].

Kogita, Akihiro ;

Togashi, Yosuke ;

Hayashi, Hidetoshi ;

Banno, Eri ;

Terashima, Masato ;

De Velasco, Marco A. ;

Sakai, Kazuko ;

Fujita, Yoshihiko ;

Tomida, Shuta ;

Takeyama, Yoshifumi ;

Okuno, Kiyotaka ;

Nakagawa, Kazuhiko ;

Nishio, Kazuto .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 46 (03) :1025-1030

[4] Understanding and targeting resistance mechanisms in NSCLC [J].

Rotow, Julia ;

Bivona, Trever G. .

NATURE REVIEWS CANCER, 2017, 17 (11) :637-658

[5] Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance [J].

Shi, Hubing ;

Moriceau, Gatien ;

Kong, Xiangju ;

Lee, Mi-Kyung ;

Lee, Hane ;

Koya, Richard C. ;

Ng, Charles ;

Chodon, Thinle ;

Scolyer, Richard A. ;

Dahlman, Kimberly B. ;

Sosman, Jeffrey A. ;

Kefford, Richard F. ;

Long, Georgina V. ;

Nelson, Stanley F. ;

Ribas, Antoni ;

Lo, Roger S. .

NATURE COMMUNICATIONS, 2012, 3

← 1 →