A Case of Intravascular Large B-cell Lymphoma (IVLBCL) with no Abnormal Findings on Chest Computed Tomography Diagnosed by Random Transbronchial Lung Biopsy

被引：14

作者：

Kaku, Norihito ^{[1
]}

Seki, Masafumi ^{[1
]}

Doi, Seiji ^{[1
]}

Hayashi, Tomayoshi ^{[2
]}

Imanishi, Daisuke ^{[3
]}

Imamura, Yoshifumi ^{[1
]}

Kurihara, Shintaro ^{[1
]}

Miyazaki, Taiga ^{[1
]}

Izumikawa, Koichi ^{[1
]}

Kakeya, Hiroshi ^{[1
]}

Yamamoto, Yoshihiro ^{[1
]}

Yanagihara, Katsunori ^{[2
]}

Tashiro, Takayoshi ^{[1
]}

Kohno, Shigeru ^{[1
]}

机构：

[1] Nagasaki Univ Hosp, Dept Internal Med 2, Nagasaki, Japan

[2] Nagasaki Univ Hosp, Dept Clin Lab, Nagasaki, Japan

[3] Nagasaki Univ, Dept Hematol, Mol Med Unit, Atom Bomb Dis Inst, Nagasaki 852, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 24期

关键词：

autoimmune hemolytic anemia (AIHA); computed tomography; fever of unknown origin (FUO); intravascular large B-cell lymphoma (IVLBCL); rituximab; transbronchial lung biopsy (TBLB); NON-HODGKINS-LYMPHOMA; MALIGNANT ANGIOENDOTHELIOMATOSIS; GALLIUM SCINTIGRAPHY;

D O I：

10.2169/internalmedicine.49.3986

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 58-year-old woman was admitted with refractory fever despite receiving broad-spectrum antibiotics. She had hypoxemia, severe anemia, elevated levels of serum lactic dehydrogenase and soluble interleukin-2 receptor, and a positive direct Coombs test, which suggested an underlying autoimmune hemolytic anemia (AIHA). Chest computed tomography (CT) showed no abnormal findings, but she had hypoxia, and her alveolar-arterial oxygen difference (A-aDO(2)) was increased. A random transbronchial lung biopsy (TBLB) was performed, and pathological analysis showed massive proliferation of tumor cells in the lumina of the small vessels. Intravascular large B-cell lymphoma (IVLBCL) was diagnosed, and her general status improved after chemotherapy.

引用

页码：2697 / 2701

页数：5

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