RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

被引：49

作者：

Collis, AJ ^{[1
]}

Foster, ML ^{[1
]}

Halley, F ^{[1
]}

Maslen, C ^{[1
]}

McLay, IM ^{[1
]}

Page, KM ^{[1
]}

Redford, EJ ^{[1
]}

Souness, JE ^{[1
]}

Wilsher, NE ^{[1
]}

机构：

[1] Dagenham Res Ctr, Aventis Pharma, Dagenham RM10 7XS, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(01)00034-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Following the discovery of RPR200765, a series of pyrimidine analogues have been prepared as backups. Amongst them, RPR203494 was identified with a better in vitro profile than RPR200765A. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：693 / 696

页数：4

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