Kv1.3: a potential pharmacological target for diabetes

被引:19
作者
Choi, Bok Hee [2 ]
Hahn, Sang June [1 ]
机构
[1] Catholic Univ Korea, Dept Physiol, Coll Med, Med Res Ctr, Seoul 137701, South Korea
[2] Chonbuk Natl Univ, Sch Med, Dept Pharmacol, Inst Med Sci, Jeonju 561180, Jeonbuk, South Korea
关键词
Kv1.3; K+ channels; diabetes; insulin; rosiglitazone; POTASSIUM CHANNEL KV1.3; TUMOR-NECROSIS-FACTOR; PANCREATIC B-CELLS; VOLTAGE-GATED K; INSULIN-RESISTANCE; THERAPEUTIC TARGET; BODY-WEIGHT; EXPRESSION; GLUCOSE; TRAFFICKING;
D O I
10.1038/aps.2010.133
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
K+ channels, which are ubiquitous membrane proteins, play a central role in regulating the resting membrane potential and the shape and duration of the action potential in pancreatic beta-cells. There are at least three types of K+ channels (K-ATP, K-Ca, and Kv2.1 channels) that are involved in glucose-stimulated insulin secretion in pancreatic beta-cells, and one type (Kv1.3) that is associated with the regulation of insulin sensitivity in peripheral target tissues. This article reviews the function of Kv1.3 channels that contribute to mediating insulin action in insulin-sensitive tissues. Pharmacological strategies for targeting Kv1.3 are then discussed with a focus on a rationale for the potential therapeutic use of Kv1.3 blocker in diabetic treatment.
引用
收藏
页码:1031 / 1035
页数:5
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