Gas-Generating, pH-Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast-Enhanced Ultrasound Imaging

被引：22

作者：

Vidallon, Mark Louis P. ^{[1
]}

Douek, Alon M. ^{[2
]}

Quek, Adam ^{[3
]}

McLiesh, Heather ^{[4
]}

Kaslin, Jan ^{[2
]}

Tabor, Rico F. ^{[1
]}

Bishop, Alexis I. ^{[5
]}

Teo, Boon Mian ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

[2] Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, Australia

[3] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[4] Monash Univ, BioPRIA, BioResource Proc Res Inst Australia, Dept Chem Engn, Clayton, Vic 3800, Australia

[5] Monash Univ, Sch Phys & Astron, Clayton, Vic 3800, Australia

来源：

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | 2020年 / 37卷 / 02期

关键词：

calcium carbonate nanoparticles; contrast enhanced ultrasound imaging; protein corona; red blood cell membranes; THERANOSTIC AGENT; NANOPARTICLES; POLYDOPAMINE; MICROBUBBLES; THERAPY; FUNCTIONALIZATION; MEMBRANE;

D O I：

10.1002/ppsc.201900471

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This work reports the fabrication of biocompatible and pH-sensitive hybrid polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO3) particles via a rapid precipitation method. These hybrid particles generate hyperechogenic carbon dioxide bubbles upon exposure to low pH environments, making them ideal as a contrast agent and detector for tumor cells. This study also highlights the application of red blood cell membrane (RBC)-derived membranes as a biomimetic coating for PDA/BSA/CaCO3 hybrid particles in order to modulate protein corona formation, a natural physiological response that alters tailored properties of most nanomaterials that are administered systemically. Results of this work demonstrate that the RBC membrane-coated hybrid particles are ideal for a wide range of biomedical applications, such as noninvasive multimodal imaging, photothermal and photodynamic therapy, and "personalized" drug delivery systems.

引用

页数：8

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