Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications

被引：74

作者：

Citarella, Andrea ^{[1
]}

Moi, Davide ^{[1
]}

Pinzi, Luca ^{[1
]}

Bonanni, Davide ^{[1
]}

Rastelli, Giulio ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Life Sci, I-41125 Modena, Italy

来源：

ACS OMEGA | 2021年 / 6卷 / 34期

关键词：

BINDING MODE; INHIBITOR;

D O I：

10.1021/acsomega.1c03628

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs, such functional groups acquired even more notoriety in synthetic medicinal chemistry. The ability of hydroxamic acids (HAs) to chelate metal ions makes this moiety an attractive metal binding group-in particular, Fe(III) and Zn(II)-so that HA derivatives find wide applications as metalloenzymes inhibitors. In this minireview, we will discuss the most relevant features concerning hydroxamic acid derivatives. In a first instance, the physicochemical characteristics of HAs will be summarized; then, an exhaustive description of the most relevant methods for the introduction of such moiety into organic substrates and an overview of their uses in medicinal chemistry will be presented.

引用

页码：21843 / 21849

页数：7

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