Three-Component Reactions of 2-Alkynylbenzaldoximes and α,β-Unsaturated Carbonyl Compounds with Bromine or Iodine Monochloride

被引：29
作者：
Ye, Shengqing [1 ]
Gao, Ke [1 ]
Wu, Jie [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 10期
基金：
中国国家自然科学基金;
关键词：
2-alkynylbenzaldoximes; bromine; 2-(4-haloisoquinolin-1-yl)ethanols; iodine monochloride; alpha; beta-unsaturated carbonyl compounds; HIGHLY STEREOSELECTIVE-SYNTHESIS; MEDIATED ELECTROPHILIC CYCLIZATION; MULTICOMPONENT REACTIONS; SUBSTITUTED ISOQUINOLINES; BENZODIAZEPINE-RECEPTOR; ORGANIC-SYNTHESIS; SILVER TRIFLATE; TANDEM; DERIVATIVES; PYRIDINES;
D O I：
10.1002/adsc.201000080
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The three-component reaction of 2-alkynylbenzaldoximes and alpha,beta-unsaturated carbonyl compounds with bromine or iodine monochloride is described, which generates the unexpected 2-(4-halo-isoquinolin-1-yl)ethanol derivatives in good to excellent yields.
引用
收藏
页码：1746 / 1751
页数：6
相关论文
共 76 条
  • [1] [Anonymous], 2001, ANGEW CHEM
  • [2] [Anonymous], 2000, ANGEW CHEM
  • [3] [Anonymous], 1998, The Isoquinoline Alkaloids
  • [4] [Anonymous], 2008, ANGEW CHEM
  • [5] Arya P, 2001, ANGEW CHEM INT EDIT, V40, P339, DOI 10.1002/1521-3773(20010119)40:2<339::AID-ANIE339>3.0.CO
  • [6] 2-J
  • [7] Balasubramanian M., 1996, COMPREHENSIVE HETERO, V5, P245, DOI 10.1016/B978-008096518-5.00109
  • [8] Pd-assisted multicomponent synthesis of heterocycles
    Balme, G
    Bossharth, E
    Monteiro, N
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (21) : 4101 - 4111
  • [9] Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO
  • [10] 2-A
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