Synthesis of a model DEF-ring core of hexacyclinic acid

被引：28

作者：

Clarke, PA

Grist, M

Ebden, M

Wilson, C

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] AstraZeneca R&D, Med Chem, Loughborough LE11 5RH, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 13期

关键词：

D O I：

10.1039/b303706a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first synthesis of a DEF-ring system of hexacyclinic acid is reported. The key steps being an intramolecular Pd(0) pi-pallyl substitution reaction, followed by a transannular iodocyclisation with acetyl hypoiodite.

引用

页码：1560 / 1561

页数：2

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