Electro-oxidation and determination of 2-thiouracil at TiO2 nanoparticles-modified gold electrode

被引：23
作者：
Bukkitgar, Shikandar D. [1 ]
Shetti, Nagaraj P. [1 ]
Kulkarni, Raviraj M. [2 ]
机构：
[1] Visvesvaraya Technol Univ, KLE Inst Technol, Dept Chem, Electrochem & Mat Grp, Hubballi Belagavi 580030, Karnataka, India
[2] Visvesvaraya Technol Univ, KLS Gogte Inst Technol, Dept Chem, Belagavi 590008, Karnataka, India
来源：
SURFACES AND INTERFACES | 2017年 / 6卷
关键词：
Cyclic voltammetry; 2-Thiouracil; Electrode; Reaction mechanism; Heterogeneous rate constant; ANTICANCER DRUG 5-FLUOROURACIL; LOOP DIURETIC FUROSEMIDE; WALLED CARBON NANOTUBES; ELECTROCHEMICAL OXIDATION; OPTICAL-PROPERTIES; PASTE ELECTRODE; BEHAVIOR; ANATASE; SENSOR; NIMESULIDE;
D O I：
10.1016/j.surfin.2017.01.003
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Electrochemical behavior studies were carried out for 2-thiouracil, using TiO2 nanoparticles modified gold electrode. As compared with the bare electrode, there was appreciable enhancement in the peak current and sensitivity for the modified electrode. The effect of pH was investigated in the range of 3.0-11.2 pH. Scan rate variation were performed to calculate the number of electrons transferred, heterogeneous rate constant and diffusion coefficient. A probable electrode reaction mechanism was proposed for 2-thiouracil in the present work. A differential voltammetric technique was used for the analytical application in the range of 1.0 x 10(-7) M-5.0 x10(-8) M. Limit of detection and quantification were calculated and found to be 1.68 nM and 5.60 nM. The proposed method was applied for the determination of 2-thiouracil in pharmaceutical and human urine samples. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：127 / 133
页数：7
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