The role of hypoxia in pancreatic cancer: a potential therapeutic target?

被引：117

作者：

Erkan, Mert ^{[1
]}

Kurtoglu, Metin ^{[2
]}

Kleeff, Jorg ^{[3
,4
]}

机构：

[1] Koc Univ, Sch Med, Dept Surg, Istanbul, Turkey

[2] Koc Univ, Sch Med, Dept Oncol, Istanbul, Turkey

[3] Royal Liverpool & Broadgreen Univ Hosp, Dept Surg, Liverpool, Merseyside, England

[4] Univ Dusseldorf, Univ Hosp Dusseldorf, Dept General Visceral & Pediat Surg, Dusseldorf, Germany

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2016年 / 10卷 / 03期

关键词：

PEGPH20; Pancreatic cancer; desmoplasia; metabolism; hypoxia; cancer stem cell; epithelial-to-mesenchymal transition; TH-302; EPITHELIAL-MESENCHYMAL TRANSITION; REDUCTIVE GLUTAMINE-METABOLISM; MTOR INHIBITOR EVEROLIMUS; INDUCIBLE FACTOR-1-ALPHA; CELL-DEATH; STELLATE CELLS; SUPEROXIDE-DISMUTASE; ALPHA-KETOGLUTARATE; PROGNOSTIC MARKER; UP-REGULATION;

D O I：

10.1586/17474124.2016.1117386

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

One of the key factors that correlates with poor survival of patients with pancreatic cancer is the extent of hypoxic areas within the tumor tissue. The adaptation of pancreatic cancer cells to limited oxygen delivery promotes the induction of an invasive and treatment-resistant phenotype, triggering metastases at an early stage of tumor development, which resist in most cases adjuvant therapies following tumor resection. In this article, the authors summarize the evidence demonstrating the significance of hypoxia in pancreatic cancer pathogenesis and discuss the possible hypoxia-induced mechanisms underlying its aggressive nature. We then conclude with promising strategies that target hypoxia-adapted pancreatic cancer cells.

引用

收藏

页码：301 / 316

页数：16

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