Training dose and session time as contextual determinants of heroin self-administration in rats

被引:19
作者
Martin, TJ [1 ]
Smith, JE [1 ]
Dworkin, SI [1 ]
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Ctr Neurobiol Invest Drug Abuse, Winston Salem, NC 27157 USA
关键词
reinforcement; antagonism; naltrexone; naltrindole; opioid; mu-opioid; delta-opioid;
D O I
10.1016/S0091-3057(97)00599-6
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In this study a rat self-administration model was used to examine the effects of training dose and time in the session on the dose-effect curve for heroin. Doses of heroin lower than 5.4 mu g/inf maintained higher rates of drug intake in animals trained with 5.4 mu g/inf compared to 18 mu g/inf. Doses greater than 5.4 mu g/inf maintained similar rates of intake in both groups of animals. The dose-response curve was shifted downward and to the right as the session progressed for animals trained with 5.4 mu g/inf of heroin; however, the shift in the dose-intake curve over the session was less pronounced when the training dose was 18 mu g/inf. Naltrexone and naltrindole were administered to animals in which responding was engendered with infusions of 5.4 mu g of heroin to determine the effects of these antagonists in the context of time is the session. The potency of naltrexone decreased across the 4 h of the session with a time course that was consistent with literature reports on the elimination kinetics of naltrexone in rat brain. In contrast, there was not a significant interaction between naltrindole dose and session time. Therefore, the rates of heroin intake in rats are dependent not only upon the dose available for self-administration, but upon the session time and training dose as well. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:415 / 421
页数:7
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