Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

被引:243
作者
Merrell, Allyson J.
Stanger, Ben Z. [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Dept Med, 421 Curie Blvd, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
ZEBRAFISH HEART REGENERATION; STEM-CELLS; BASAL-CELLS; SELF-RENEWAL; DIRECT CONVERSION; PROGENITOR CELLS; SMALL-INTESTINE; DORSAL IRIS; LIVER; FIBROBLASTS;
D O I
10.1038/nrm.2016.24
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Biologists have long been intrigued by the possibility that cells can change their identity, a phenomenon known as cellular plasticity. The discovery that terminally differentiated cells can be experimentally coaxed to become pluripotent has invigorated the field, and recent studies have demonstrated that changes in cell identity are not limited to the laboratory. Specifically, certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as part of an organ's normal injury response. Recent studies have highlighted the extent to which cell plasticity contributes to tissue homeostasis, findings that have implications for cell-based therapy.
引用
收藏
页码:413 / 425
页数:13
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