The Immunogenetics of Psoriasis and Implications for Drug Repositioning

被引：18

作者：

Xu, Xuan ^{[1
]}

Zhang, Hong-Yu ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan 430070, Hubei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 12期

关键词：

psoriasis; immunogenetics; genetics; susceptible genes; drug repositioning; GENERALIZED PUSTULAR PSORIASIS; SEVERE PLAQUE PSORIASIS; ERYTHRODERMIC PSORIASIS; MEDICAL GENETICS; SKIN-DISEASE; ARTHRITIS; THERAPIES; SUSCEPTIBILITY; VARIANTS; PATHOGENESIS;

D O I：

10.3390/ijms18122650

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease's development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis.

引用

页数：12

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