Carbon Nanotubes: Solution for the Therapeutic Delivery of siRNA?

被引：43

作者：

Kirkpatrick, D. Lynn ^{[1
]}

Weiss, Michelle ^{[1
]}

Naumov, Anton ^{[1
]}

Bartholomeusz, Geoffrey ^{[2
]}

Weisman, R. Bruce ^{[3
]}

Gliko, Olga ^{[1
]}

机构：

[1] Ensysce Biosci Inc, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA

[3] Rice Univ, Dept Chem, Houston, TX 77005 USA

来源：

MATERIALS | 2012年 / 5卷 / 02期

关键词：

single-walled carbon nanotube; short interfering RNA; therapeutic delivery; NEAR-INFRARED FLUORESCENCE; IN-VIVO; DRUG-DELIVERY; PULMONARY TOXICITY; COMPLEMENT ACTIVATION; SUBCUTANEOUS TISSUE; CANCER-THERAPY; VITRO; MICE; BIODISTRIBUTION;

D O I：

10.3390/ma5020278

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Carbon nanotubes have many unique physical and chemical properties that are being widely explored for potential applications in biomedicine especially as transporters of drugs, proteins, DNA and RNA into cells. Specifically, single-walled carbon nanotubes (SWCNT) have been shown to deliver siRNA to tumors in vivo. The low toxicity, the excellent membrane penetration ability, the protection afforded against blood breakdown of the siRNA payload and the good biological activity seen in vivo suggests that SWCNT may become universal transfection vehicles for siRNA and other RNAs for therapeutic applications. This paper will introduce a short review of a number of therapeutic applications for carbon nanotubes and provide recent data suggesting SWCNT are an excellent option for the delivery of siRNA clinically.

引用

收藏

页码：278 / 301

页数：24

相关论文

共 57 条

[1] Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing [J].

Al-Jamal, Khuloud T. ;

Gherardini, Lisa ;

Bardi, Giuseppe ;

Nunes, Antonio ;

Guo, Chang ;

Bussy, Cyrill ;

Herrero, M. Antonia ;

Bianco, Alberto ;

Prato, Maurizio ;

Kostarelos, Kostas ;

Pizzorusso, Tommaso .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (27) :10952-10957

[2] Reversible control of carbon nanotube aggregation for a glucose affinity sensor [J].

Barone, Paul W. ;

Strano, Michael S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (48) :8138-8141

[3] In Vivo Therapeutic Silencing of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) Using Single-Walled Carbon Nanotubes Noncovalently Coated with siRNA [J].

Bartholomeusz, Geoffrey ;

Cherukuri, Paul ;

Kingston, John ;

Cognet, Laurent ;

Lemos, Robert, Jr. ;

Leeuw, Tonya K. ;

Gumbiner-Russo, Laura ;

Weisman, R. Bruce ;

Powis, Garth .

NANO RESEARCH, 2009, 2 (04) :279-291

[4] Advancement in carbon nanotubes: basics, biomedical applications and toxicity [J].

Beg, Sarwar ;

Rizwan, Mohammad ;

Sheikh, Asif M. ;

Hasnain, M. Saquib ;

Anwer, Khalid ;

Kohli, Kanchan .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 63 (02) :141-163

[5] Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug Delivery [J].

Bhirde, Ashwin A. ;

Patel, Vyomesh ;

Gavard, Julie ;

Zhang, Guofeng ;

Sousa, Alioscka A. ;

Masedunskas, Andrius ;

Leapman, Richard D. ;

Weigert, Roberto ;

Gutkind, J. Silvio ;

Rusling, James F. .

ACS NANO, 2009, 3 (02) :307-316

[6] Nanospearing - Biomolecule delivery and its biocompatibility [J].

Cai, Dong ;

Kempa, Krzysztof ;

Ren, Zhifeng ;

Carnahan, David ;

Chiles, Thomas C. .

NANOMATERIALS FOR APPLICATIONS IN MEDICINE AND BIOLOGY, 2008, :81-+

[7] Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence [J].

Cherukuri, Paul ;

Gannon, Christopher J. ;

Leeuw, Tonya K. ;

Schmidt, Howard K. ;

Smalley, Richard E. ;

Curley, Steven A. ;

Weisman, R. Bruce .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (50) :18882-18886

[8] Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system [J].

Gaur, U ;

Sahoo, SK ;

De, TK ;

Ghosh, PC ;

Maitra, A ;

Ghosh, PK .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 202 (1-2) :1-10

[9] Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes [J].

Ghosh, Supratim ;

Dutta, Samrat ;

Gomes, Evan ;

Carroll, David ;

D'Agostino, Ralph, Jr. ;

Olson, John ;

Guthold, Martin ;

Gmeiner, William H. .

ACS NANO, 2009, 3 (09) :2667-2673

[10] Cisplatin@US-tube carbon nanocapsules for enhanced chemotherapeutic delivery [J].

Guven, Adem ;

Rusakova, Irene A. ;

Lewis, Michael T. ;

Wilson, Lon J. .

BIOMATERIALS, 2012, 33 (05) :1455-1461

← 1 2 3 4 5 6 →