Unprecedented hetero-geometric discrete copper(II) complexes: Crystal structure and bio-mimicking of Catecholase activity

被引：29

作者：

De, Abhranil ^{[1
]}

Dey, Dhananjay ^{[1
]}

Yadav, Hare Ram ^{[2
]}

Maji, Milan ^{[3
]}

Rane, Vinayak ^{[4
]}

Kadam, R. M. ^{[4
]}

Choudhury, Angshuman Roy ^{[2
]}

Biswas, Bhaskar ^{[1
]}

机构：

[1] Raghunathpur Coll, Dept Chem, Purulia 723133, W Bengal, India

[2] Indian Inst Sci Educ & Res Mohali, Dept Chem Sci, Sect 81,SAS Nagar,Manauli PO, Mohali 140306, Punjab, India

[3] Natl Inst Technol, Dept Chem, Mahatma Gandhi Ave, Durgapur 713209, W Bengal, India

[4] Bhabha Atom Res Ctr, Radiochem Div, Bombay 400085, Maharashtra, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2016年 / 128卷 / 11期

关键词：

Copper; X-ray structure; radical activity; catechol oxidase activity; SPECTROSCOPIC CHARACTERIZATION; MOLECULAR-STRUCTURE; OXIDASE ACTIVITY; DICOPPER CENTER; DNA CLEAVAGE; DINUCLEAR; LIGAND; OXIDATION;

D O I：

10.1007/s12039-016-1186-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unprecedented solid of coper(II) complexes, [Cu(dpa)(2)NCS](2)[Cu(dpa)(2)(NCS)(2)](ClO4)(2) (1) [dpa = 2,2'-dipyridylamine; SCN = thiocyanate], has been synthesized and crystallographically characterized with the aim to study the catecholase activity. The Cu(II) complex mimics the full catalytic cycle of the active site of catechol oxidase enzyme in acetonitrile medium with a turnover number of 4.788x10(3) h (-1) along with the production of semiquinone radical and hydrogen peroxide. In situ generation of Cu(I) species in the catalytic pathway of catechol oxidation was established by electrochemical study and further confirmed by electron paramagnetic resonance (EPR) spectroscopy.

引用

页码：1775 / 1782

页数：8

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