Tris(2,4,6-trimethoxyphenyl)methyl carbenium ion for charge derivatization of amines and amino acids

被引：19

作者：

Denekamp, Chagit ^{[1
]}

Lacour, Jerome ^{[2
]}

Laleu, Benoit ^{[2
]}

Rabkin, Emilia ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

[2] Univ Geneva, Dept Chim Organ, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF MASS SPECTROMETRY | 2008年 / 43卷 / 05期

关键词：

tris(2,4,6-trimethoxyphenyl)methyl carbenium ion; MALDI-TOF; matrix; amines analysis; amino acids;

D O I：

10.1002/jms.1360

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary and secondary alkyl amines substitute readily one of the para-methoxy substituents of tris(2,4,6-trimethoxyphenyl)methyl carbenium ion. With this rapid process, the preparation of permanently charged positive derivatives of amines, amino acids and small C-protected peptides is achieved. This is utilized here to facilitate the matrix assisted laser desorption ionization-time-of-flight (MALDI-TOF) analysis of these compounds. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：623 / 627

页数：5

共 36 条

[1] Broberg S, 2000, RAPID COMMUN MASS SP, V14, P1801, DOI 10.1002/1097-0231(20001015)14:19<1801::AID-RCM96>3.0.CO
[2] 2-E
[3] Improving de novo sequencing of peptides using a charged tag and C-terminal digestion
Chen, Weibin
Lee, Peter J.
Shion, Henry
Ellor, Nicholas
Gebler, John C.
[J]. ANALYTICAL CHEMISTRY, 2007, 79 (04) : 1583 - 1590
[4] Localization of the O-glycosylated sites in peptides by fixed-charge derivatization with a phosphonium group
Czeszak, X
Morelle, W
Ricart, G
Tétaert, D
Lemoine, J
[J]. ANALYTICAL CHEMISTRY, 2004, 76 (15) : 4320 - 4324
[5] Photoelectrochemical behavior of some methylium salts having methoxyphenyl groups at an ITO electrode in 1,2-dichloroethane
Erabi, T
Ohtsuki, T
Osaki, E
Ishikawa, Y
Nagareo, T
Asahara, M
Wada, M
[J]. ELECTROCHEMISTRY, 2002, 70 (06) : 409 - 411
[6] Cyclic voltammetric characteristics of tri- and diarylcarbenium salts having some methoxyphenyl groups
Erabi, T
Ohtsuki, T
Osaki, E
Tomita, N
Asahara, M
Wada, M
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2000, 73 (10) : 2237 - 2242
[7] Derivatization of small oligosaccharides prior to analysis by matrix-assisted laser desorption/ionization using glycidyltrimethylammonium chloride and Girard's reagent T
Gouw, JW
Burgers, PC
Trikoupis, MA
Terlouw, JK
[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2002, 16 (10) : 905 - 912
[8] Derivatization in mass spectrometry - 7. On-line derivatization/degradation
Halket, JM
Zaikin, VG
[J]. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2006, 12 (01) : 1 - 13
[9] Derivatization in mass spectrometry - 5. Specific derivatization of monofunctional compounds
Halket, JM
Zaikin, VG
[J]. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2005, 11 (01) : 127 - 160
[10] Derivatization in mass spectrometry-3. Alkylation (arylation)
Halket, JM
Zaikin, VG
[J]. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2004, 10 (01) : 1 - 19

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