Plasma Levels of Platelet-Derived Microparticles in Patients with Obstructive Sleep Apnea Syndrome

被引:36
作者
Maruyama, Keiko [1 ]
Morishita, Eriko [1 ,2 ]
Sekiya, Akiko [1 ]
Omote, Mika [3 ]
Kadono, Tadaaki [3 ]
Asakura, Hidesaku [2 ]
Hashimoto, Masami [4 ]
Kobayashi, Masako [4 ]
Nakatsumi, Yasuto [4 ]
Takada, Shigeo [4 ]
Ohtake, Shigeki [1 ]
机构
[1] Kanazawa Univ, Grad Sch Med Sci, Dept Clin Lab Sci, Kanazawa, Ishikawa 9200942, Japan
[2] Kanazawa Univ, Grad Sch Med Sci, Dept Cellular Transplantat Biol, Kanazawa, Ishikawa 9200942, Japan
[3] Kanazawa Univ Hosp, Dept Clin Lab, Kanazawa, Ishikawa 920, Japan
[4] Kanazawa Municipal Hosp, Kanazawa, Ishikawa, Japan
关键词
Obstructive sleep apnea syndrome; Platelet-derived microparticles; Apnea-hypopnea index; Continuous positive airway pressure; ACTIVATION; COAGULATION; PROCOAGULANT; STRESS;
D O I
10.5551/jat.8565
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Aim: Obstructive sleep apnea syndrome (OSAS) has been associated with high cardiovascular morbidity and mortality, and patients suffer from repeated episodes of hypoxia. Platelet-derived microparticles (PDMPs) are released via platelet activation by various agonists, including inflammatory cytokines or high shear stress. Plasminogen activator inhibitor -1 (PAI-1) is a fibrinolytic marker and soluble fibrin (SF) is a coagulation activation marker. We examined plasma levels of PDMPs, PAI-1 and SF in patients with OSAS. We also examined the effects of continuous positive airway pressure (CPAP) on plasma levels of PDMPs. Methods: Full polysomnography (PSG) monitoring was performed on 27 patients. The apnea-hypopnea index (AHI) of 5 events/h or less than 30 events/h indicated mild to moderate OSAS, and an AHI of 30 events/h or more indicated severe OSAS. Plasma levels of PDMPs were measured using an ELISA kit, and PAI and SF were determined by a latex immunoassay. In addition, the effects of CPAP treatment were studied in 7 patients. Result: The plasma level of PDMPs was significantly higher in patients with severe OSAS (15.8 +/- 10.4 U/mL) than normal controls (10.8 +/- 7.1 U/mL, p < 0.05) and patients with mild to moderate OSAS (9.2 +/- 3.5 U/mL, p < 0.05). The plasma levels of PDMPs correlated with the AHI (r = 0.39, p < 0.05). In addition, CPAP treatment decreased the plasma level of PDMPs (11.9 +/- 5.6 U/mL to 6.7 +/- 3.2 U/mL, p < 0.05). Conclusions: Patients with OSAS might be at increased cardiovascular risk due to elevated PDMPs. Moreover a decrease in the plasma level of PDMPs by treatment with CPAP might reduce cardiovascular risk.
引用
收藏
页码:98 / 104
页数:7
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