Biomarker Use in Colorectal Cancer Therapy

被引：29

作者：

Kelley, Robin K. ^{[1
]}

Wang, Grace ^{[2
]}

Venook, Alan P.

机构：

[1] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Med, San Francisco, CA 94115 USA

[2] UCSF, Ctr Translat & Policy Res Personalized Med, San Francisco, CA USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2011年 / 9卷 / 11期

关键词：

Colon cancer; colorectal cancer; biomarker; KRAS; BRAF; microsatellite instability; mismatch repair; REVISED BETHESDA GUIDELINES; DEFECTIVE MISMATCH REPAIR; CIRCULATING TUMOR-CELLS; MICROSATELLITE-INSTABILITY; ADJUVANT CHEMOTHERAPY; COLON-CANCER; LYNCH-SYNDROME; PREDICTIVE BIOMARKERS; MOLECULAR PREDICTORS; THYMIDYLATE SYNTHASE;

D O I：

10.6004/jnccn.2011.0105

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Biomarkers reflective of the molecular and genetic heterogeneity in colorectal cancers now guide certain aspects of clinical management and offer great potential for enrichment, stratification, and identification of novel therapeutic targets in drug development. Using case-based examples, this article reviews biomarkers that have an established role in the clinical management of colorectal cancer: mismatch repair protein testing and KRAS and BRAF mutational analysis. A selection of biomarkers undergoing validation for future clinical application is presented, and the dynamic and challenging interface between biomarkers in research and clinical practice is discussed. (JNCCN 2011;9:1293-1303)

引用

页码：1293 / 1302

页数：10

共 71 条

[51] Systematic review of microsatellite instability and colorectal cancer prognosis [J].

Popat, S ;

Hubner, R ;

Houlston, RS .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (03) :609-618

[52] Meta-analysis Shows That Detection of Circulating Tumor Cells Indicates Poor Prognosis in Patients With Colorectal Cancer [J].

Rahbari, Nuh N. ;

Aigner, Maximilian ;

Thorlund, Kristian ;

Mollberg, Nathan ;

Motschall, Edith ;

Jensen, Katrin ;

Diener, Markus K. ;

Buechler, Markus W. ;

Koch, Moritz ;

Weitz, Juergen .

GASTROENTEROLOGY, 2010, 138 (05) :1714-U20

[53] Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer [J].

Ribic, CM ;

Sargent, DJ ;

Moore, MJ ;

Thibodeau, SN ;

French, AJ ;

Goldberg, RM ;

Hamilton, SR ;

Laurent-Puig, P ;

Gryfe, R ;

Shepherd, LE ;

Tu, D ;

Redston, M ;

Gallinger, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (03) :247-257

[54] Prognostic Role of KRAS and BRAF in Stage II and III Resected Colon Cancer: Results of the Translational Study on the PETACC-3, EORTC 40993, SAKK 60-00 Trial [J].

Roth, Arnaud D. ;

Tejpar, Sabine ;

Delorenzi, Mauro ;

Yan, Pu ;

Fiocca, Roberto ;

Klingbiel, Dirk ;

Dietrich, Daniel ;

Biesmans, Bart ;

Bodoky, Gyoergy ;

Barone, Carlo ;

Aranda, Enrique ;

Nordlinger, Bernard ;

Cisar, Laura ;

Labianca, Roberto ;

Cunningham, David ;

Van Cutsem, Eric ;

Bosman, Fred .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (03) :466-474

[55] The PARSC trial, a prospective study for the assessment of recurrence risk in stage II colon cancer (CC) patients using ColoPrint [J].

Salazar, R. ;

Marshall, J. ;

Stork-Sloots, L. ;

Simon, I. ;

Holzik, M. Lutke ;

Tabernero, J. ;

Van Der Hoeven, J. J. ;

Bibeau, F. ;

Rosenberg, R. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)

[56] Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer [J].

Salazar, Ramon ;

Roepman, Paul ;

Capella, Gabriel ;

Moreno, Victor ;

Simon, Iris ;

Dreezen, Christa ;

Lopez-Doriga, Adriana ;

Santos, Cristina ;

Marijnen, Corrie ;

Westerga, Johan ;

Bruin, Sjoerd ;

Kerr, David ;

Kuppen, Peter ;

van de Velde, Cornelis ;

Morreau, Hans ;

Van Velthuysen, Loes ;

Glas, Annuska M. ;

Van't Veer, Laura J. ;

Tollenaar, Rob .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (01) :17-24

[57]

Salonga D, 2000, CLIN CANCER RES, V6, P1322

[58]

Samowitz WS, 2001, CANCER EPIDEM BIOMAR, V10, P917

[59] Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer [J].

Sargent, Daniel J. ;

Marsoni, Silvia ;

Monges, Genevieve ;

Thibodeau, Stephen N. ;

Labianca, Roberto ;

Hamilton, Stanley R. ;

French, Amy J. ;

Kabat, Brian ;

Foster, Nathan R. ;

Torri, Valter ;

Ribic, Christine ;

Grothey, Axel ;

Moore, Malcolm ;

Zaniboni, Alberto ;

Seitz, Jean-Francois ;

Sinicrope, Frank ;

Gallinger, Steven .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (20) :3219-3226

[60]

Siegel RL, 2021, CA-CANCER J CLIN, V71, P7, DOI [10.3322/caac.21654, 10.3322/caac.21387, 10.3322/caac.21669]

← 1 2 3 4 5 6 7 8 →