The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rγnull mice

被引：0
作者：
Ishikawa, F. [1 ]
Saito, Y. [1 ,4 ]
Yoshida, S. [1 ]
Harada, M. [2 ]
Shultz, L. D. [3 ]
机构：
[1] RIKEN, Res Ctr Allergy & Immunol, Res Unit Human Dis Model, Tsurumi Ku, Kanagawa 2300045, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Dept Biosyst Med, Fukuoka 812, Japan
[3] Jackson Lab, Bar Harbor, ME 04609 USA
[4] Tokai Univ, Sch Med, Dept Breast & Endocrine Surg, Kanagawa 2591100, Japan
来源：
HUMANIZED MICE | 2008年 / 324卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Biomedical research including immunology and stem cell biology has developed greatly because of the evolving technology of gene modification and conventional transplantation methods using the most common experimental laboratory animal, the mouse. To translate promising research findings based on mouse research into clinical medicine, however, we need to clarify whether similar events take place in humans. In the study of hematology and immunology, humanized mice provide a unique and efficient experimental system to evaluate differentiation, function, and interaction of human blood cells or immune components. Here we review the latest experimental findings in the fields of immunology, stem cell biology, and regenerative medicine using humanized mice.
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页码：87 / 94
页数：8
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