A novel three-component reaction of anilines, formaldehyde and dimedone: simple synthesis of spirosubstituted piperidines

被引：46
作者：
Kozlov, Nikolas G. [1 ]
Kadutskii, Aliaksei P. [1 ]
机构：
[1] Natl Acad Sci Belarus, Inst Phys Organ Chem, Lab Organ Catalysis, Minsk 220072, BELARUS
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 29-30期
关键词：
beta-diketones; multicomponent reaction; mannich reaction; azaspiro compounds; piperidines;
D O I：
10.1016/j.tetlet.2008.04.160
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A three-component condensation of anilines with dimedone and formaldehyde leads to the formation of 3,5-dispirosubstituted piperidines. This simple reaction can serve as a convenient source of 3,5-disubstituted piperidines as well as polyfunctional 3-spirofused piperidines. (c) 2008 Elsevier Ltd. All rights reserved.
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收藏
页码：4560 / 4562
页数：3
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