New regiospecific synthesis of 2-trifluoromethyl-1,5 diazapentadiene compounds and of 2-trifluoromethylquinolines, their cyclization products

被引：19

作者：

El Kharrat, S ^{[1
]}

Skander, M ^{[1
]}

Dahmani, A ^{[1
]}

Laurent, P ^{[1
]}

Blancou, H ^{[1
]}

机构：

[1] Univ Montpellier 2, Lab Chim Organ Org Mol Evolut & Mat Fluores, F-34095 Montpellier, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 21期

关键词：

D O I：

10.1021/jo050586d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Trifluoromethylquinolines 5 are synthesized in high yields using a perfluoroalkylated gemiodoacetoxy derivative 3 and arylamines 4. The intermediate of this reaction, 2-trifluoromethyl-1,5-diazapentadiene compound 6, was isolated. The procedures are easy, and yields are in general high. This sequence represents a valuable new synthesis of substituted 2-trifluoromethylquinolines and of 2-trifluoromethyl-diazapentadienes (vinamidine compounds).

引用

页码：8327 / 8331

页数：5

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