The Effects of Fructose Intake on Serum Uric Acid Vary among Controlled Dietary Trials

被引：149

作者：

Wang, D. David ^{[1
,4
]}

Sievenpiper, John L. ^{[1
,7
]}

de Souza, Russell J. ^{[1
,4
,8
,9
]}

Chiavaroli, Laura ^{[1
,4
]}

Ha, Vanessa ^{[1
,4
]}

Cozma, Adrian I. ^{[1
,4
]}

Mirrahimi, Arash ^{[1
,4
]}

Yu, Matthew E. ^{[1
,4
]}

Carleton, Amanda J. ^{[1
,6
]}

Di Buono, Marco ^{[10
]}

Jenkins, Alexandra L. ^{[1
]}

Leiter, Lawrence A. ^{[1
,2
,3
,4
,5
]}

Wolever, Thomas M. S. ^{[1
,2
,3
,4
,5
]}

Beyene, Joseph ^{[8
,11
,12
]}

Kendall, Cyril W. C. ^{[1
,4
,13
]}

Jenkins, David J. A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON, Canada

[2] St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[3] St Michaels Hosp, Div Endocrinol, Toronto, ON, Canada

[4] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada

[5] Univ Toronto, Fac Med, Dept Med, Toronto, ON, Canada

[6] Univ Toronto, Fac Med, Dept Undergrad Med Educ, MD Program, Toronto, ON, Canada

[7] McMaster Univ, Fac Hlth Sci, Dept Pathol & Mol Med, Hamilton, ON, Canada

[8] McMaster Univ, Fac Hlth Sci, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[9] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[10] Heart & Stroke Fdn Ontario, Toronto, ON, Canada

[11] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[12] Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada

[13] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada

来源：

JOURNAL OF NUTRITION | 2012年 / 142卷 / 05期

基金：

加拿大健康研究院;

关键词：

3RD NATIONAL-HEALTH; METABOLIC SYNDROME; NATURAL SWEETENER; HYPERURICEMIA; SUGAR; MEN; METAANALYSES; GLUCOSE; PREVALENCE; PARAMETERS;

D O I：

10.3945/jn.111.151951

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Hyperuricemia is linked to gout and features of metabolic syndrome. There is concern that dietary fructose may increase uric acid concentrations. To assess the effects of fructose on serum uric acid concentrations in people with and without diabetes, we conducted a systematic review and meta-analysis of controlled feeding trials. We searched MEDLINE, EMBASE, and the Cochrane Library for relevant trials (through August 19, 2011). Analyses included all controlled feeding trials >= 7 d investigating the effect of fructose feeding on uric acid under isocaloric conditions, where fructose was isocalorically exchanged with other carbohydrate, or hypercaloric conditions, and where a control diet was supplemented with excess energy from fructose. Data were aggregated by the generic inverse variance method using random effects models and expressed as mean difference (MD) with 95% Cl. Heterogeneity was assessed by the 0 statistic and quantified by I-2. A total of 21 trials in 425 participants met the eligibility criteria. Isocaloric exchange of fructose for other carbohydrate did not affect serum uric acid in diabetic and nondiabetic participants [MD = 0.56 mu mol/L (95% Cl: -6.62, 7.74)], with no evidence of inter-study heterogeneity. Hypercaloric supplementation of control diets with fructose (+35% excess energy) at extreme doses (213-219 g/d) significantly increased serum uric acid compared with the control diets alone in nondiabetic participants [MD = 31.0 mmol/L (95% Cl: 15.4, 46.5)] with no evidence of heterogeneity. Confounding from excess energy cannot be ruled out in the hypercaloric trials. These analyses do not support a uric acid-increasing effect of isocaloric fructose intake in nondiabetic and diabetic participants. Hypercaloric fructose intake may, however, increase uric acid concentrations. The effect of the interaction of energy and fructose remains unclear. Larger, well-designed trials of fructose feeding at "real world" doses are needed. J. Nutr. 142: 916-923, 2012.

引用

页码：916 / 923

页数：8

共 52 条

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