Molecularly imprinted polymer for label-free integrated optical waveguide bio(mimetic)sensors

被引：11
作者：
Barrios, C. A. [1 ]
Carrasco, S. [2 ]
Francesca, M. [1 ,3 ]
Yurrita, P. [1 ]
Navarro-Villoslada, F. [2 ]
Moreno-Bondi, M. C. [2 ]
机构：
[1] Univ Politecn Madrid, ISOM, ETSI Telecomunicac, E-28040 Madrid, Spain
[2] Univ Complutense, Fac Chem, Dpt Analyt Chem, Optochem Sensors & Appl Photochem Grp CSOLFA, E-28040 Madrid, Spain
[3] Politecn Milan, Fac Ingn Informaz, Milan, Italy
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2012年 / 161卷 / 01期
关键词：
Biosensors; Optical properties of photonic materials; Theory and design; Waveguide devices; DEVICES;
D O I：
10.1016/j.snb.2011.11.008
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A molecularly imprinted polymer (MIP) has been developed and characterized as a photonic material for integrated optics based antibiotic sensing. Key parameters - refractive index, optical attenuation and porosity - of the synthesized polymer have been determined by employing two light transmission methods: visible/near-infrared spectrophotometry and efficiency measurement of transmissive polymer diffraction gratings. In both cases, the porous polymer samples were infiltrated with colorless liquids with different refractive indexes, modulating the material optical behavior. The MIP optical response to target molecule (antibiotic enrofloxacin) has been also studied via optical diffraction. Based on the measured optical parameters and molecule recognition response, a Si3N4/SiO2 strip waveguide sensor with a MIP sensing layer has been proposed and designed by numerical waveguide modeling. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：607 / 614
页数：8
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