Visible light mediated C-H trifluoromethylation of (hetero)arenes

被引：21

作者：

Xiao, Fang ^{[1
,2
]}

Jin-Hong Lin ^{[2
,3
]}

Hao, Fei ^{[2
,4
]}

Zheng, Xing ^{[1
]}

Guo, Yu ^{[1
]}

Ji-Chang Xiao ^{[2
]}

机构：

[1] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China

[2] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[3] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China

[4] Qilu Univ Technol, Shandong Acad Sci, Shandong Prov Key Lab Mol Engn, Jinan 250353, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 07期

关键词：

PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; CATALYZED TRIFLUOROMETHYLATION; AROMATIC-COMPOUNDS; ARENES; FLUORINE; PERFLUOROALKYLATION; HETEROARENES;

D O I：

10.1039/d2qo00067a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol for visible light mediated C-H trifluoromethylation of unactivated (hetero)arenes under blue LED irradiation has been developed. The reaction enables the rapid construction of a range of CF3-containing (hetero)arenes in moderate to high yields from the readily accessible trifluoromethylsulfonyl-pyridinium salt (TFSP). This protocol is also suitable for nitrogen-containing aromatic heterocycles, which are potentially useful in medicinal chemistry.

引用

页码：1982 / 1985

页数：4

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