Visible light mediated C-H trifluoromethylation of (hetero)arenes

被引：18
|
作者：
Xiao, Fang [1 ,2 ]
Jin-Hong Lin [2 ,3 ]
Hao, Fei [2 ,4 ]
Zheng, Xing [1 ]
Guo, Yu [1 ]
Ji-Chang Xiao [2 ]
机构：
[1] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China
[2] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[3] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China
[4] Qilu Univ Technol, Shandong Acad Sci, Shandong Prov Key Lab Mol Engn, Jinan 250353, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 07期
关键词：
PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; CATALYZED TRIFLUOROMETHYLATION; AROMATIC-COMPOUNDS; ARENES; FLUORINE; PERFLUOROALKYLATION; HETEROARENES;
D O I：
10.1039/d2qo00067a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A protocol for visible light mediated C-H trifluoromethylation of unactivated (hetero)arenes under blue LED irradiation has been developed. The reaction enables the rapid construction of a range of CF3-containing (hetero)arenes in moderate to high yields from the readily accessible trifluoromethylsulfonyl-pyridinium salt (TFSP). This protocol is also suitable for nitrogen-containing aromatic heterocycles, which are potentially useful in medicinal chemistry.
引用
收藏
页码：1982 / 1985
页数：4
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