Newborn neurons in the adult olfactory bulb: Unique properties for specific odor behavior

被引:47
作者
Breton-Provencher, Vincent [1 ]
Saghatelyan, Armen [1 ,2 ]
机构
[1] Univ Laval, CRULRG, Cellular Neurobiol Unit, Quebec City, PQ G1J 2G3, Canada
[2] Univ Laval, Dept Psychiat & Neurosci, Quebec City, PQ G1K 7P4, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Adult neurogenesis; Olfactory bulb; Interneurons; Functional implication; Odor behavior; CENTER-SURROUND INHIBITION; NEWLY GENERATED NEURONS; NEURAL STEM-CELLS; GRANULE CELLS; SUBVENTRICULAR ZONE; STIMULATED NEUROGENESIS; SYNAPTIC INHIBITION; GAMMA-OSCILLATIONS; LATERAL INHIBITION; GLOMERULAR LAYER;
D O I
10.1016/j.bbr.2011.08.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The generation of new cells in the adult brain reveals a new form of plasticity in the neuronal network. New cells are constantly migrating to and integrating into the pre-existing neuronal network in the olfactory bulb. The exact role of new neurons in the adult olfactory bulb and in odor behavior remains elusive despite continuous progress. The unique properties of these adult-born interneurons that distinguish them from pre-existing bulbar neurons allow them to adapt the processing of odor information in the neuronal network of the olfactory bulb in response to sensory experience. The combination of diverse methods for modulating neurogenesis levels with distinct behavioral paradigms has revealed that interneurons generated during adulthood play a role in olfactory behavior. In this review we provide an overview of the unique properties of adult-born neurons that integrate into the olfactory bulb as well as their role in odor behavior. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:480 / 489
页数:10
相关论文
共 100 条
[1]   Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice [J].
Abraham, Nixon M. ;
Egger, Veronica ;
Shimshek, Derya R. ;
Renden, Robert ;
Fukunaga, Izumi ;
Sprengel, Rolf ;
Seeburg, Peter H. ;
Klugmann, Matthias ;
Margrie, Troy W. ;
Schaefer, Andreas T. ;
Kuner, Thomas .
NEURON, 2010, 65 (03) :399-411
[2]   Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb [J].
Alonso, Mariana ;
Viollet, Cecile ;
Gabellec, Marie-Madeleine ;
Meas-Yedid, Vannary ;
Olivo-Marin, Jean-Christophe ;
Lledo, Pierre-Marie .
JOURNAL OF NEUROSCIENCE, 2006, 26 (41) :10508-10513
[3]   Neurogenesis in adult subventricular zone [J].
Alvarez-Buylla, A ;
García-Verdugo, JM .
JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :629-634
[4]   Activity-dependent gating of lateral inhibition in the mouse olfactory bulb [J].
Arevian, Armen C. ;
Kapoor, Vikrant ;
Urban, Nathaniel N. .
NATURE NEUROSCIENCE, 2008, 11 (01) :80-87
[5]   Centre-surround inhibition among olfactory bulb glomeruli [J].
Aungst, JL ;
Heyward, PM ;
Puche, AC ;
Karnup, SV ;
Hayar, A ;
Szabo, G ;
Shipley, MT .
NATURE, 2003, 426 (6967) :623-629
[6]   Adult neurogenesis and specific replacement of interneuron subtypes in the mouse main olfactory bulb [J].
Bagley, Joshua ;
LaRocca, Greg ;
Jimenez, Daniel A. ;
Urban, Nathaniel N. .
BMC NEUROSCIENCE, 2007, 8 (1)
[7]  
Barkai E, 2001, REV NEUROSCIENCE, V12, P111
[8]   Role of Sensory Activity on Chemospecific Populations of Interneurons in the Adult Olfactory Bulb [J].
Bastien-Dionne, Pierre-Olivier ;
David, Linda S. ;
Parent, Andre ;
Saghatelyan, Armen .
JOURNAL OF COMPARATIVE NEUROLOGY, 2010, 518 (10) :1847-1861
[9]   Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination [J].
Bath, Kevin G. ;
Mandairon, Nathalie ;
Jing, Deqiang ;
Rajagopal, Rithwick ;
Kapoor, Ruchi ;
Chen, Zhe-Yu ;
Khan, Tanvir ;
Proenca, Catia C. ;
Kraemer, Rosemary ;
Cleland, Thomas A. ;
Hempstead, Barbara L. ;
Chao, Moses V. ;
Lee, Francis S. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (10) :2383-2393
[10]  
Belluzzi O, 2003, J NEUROSCI, V23, P10411