Sterilisation of collagen materials using hydrogen peroxide doted supercritical carbon dioxide and its effects on the materials properties

被引：19

作者：

Meyer, Michael ^{[1
]}

Prade, Ina ^{[1
]}

Leppchen-Froehlich, Kathrin ^{[1
]}

Felix, Alexander ^{[2
]}

Herdegen, Volker ^{[2
]}

Haseneder, Roland ^{[2
]}

Repke, Jens-Uwe ^{[2
]}

机构：

[1] Forschungsinst Leder & Kunststoffbahnen, Freiberg, Germany

[2] Tech Univ Bergakad Freiberg, ITUN, D-09596 Freiberg, Germany

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2015年 / 102卷

关键词：

Supercritical carbondioxide; Hydrogen peroxide; Collagen; Sterilisation; BIOMATERIAL; INACTIVATION; OXIDATION; DEVICES; SPORES;

D O I：

10.1016/j.supflu.2015.04.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Collagen sponges and membranes which are used as medical device and in tissue engineering (TE) were sterilised by using supercritical carbon dioxide (CO2sc) which was doted with hydrogen peroxide (300 mg/L). Sterilisation was achieved by pressure change treatment (20.5-10 MPa). Neither physical nor structural and biological parameters of the materials were negatively affected. In contrast, sterilisation by gamma-irradiation led to increased solubility and decreased physical stability. As H2O2 is a common chemical used in collagen processing in industrial scale this could become a sterilisation technique for medical devices and TE materials on collagen basis. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：32 / 39

页数：8

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