Role of pyroptosis in cardiovascular diseases

被引：191

作者：

Jia, Chang ^{[1
,2
]}

Chen, Huanwen ^{[4
]}

Zhang, Jian ^{[2
,3
]}

Zhou, Kailiang ^{[2
,5
]}

Zhuge, Yingzhi ^{[2
,3
]}

Niu, Chao ^{[1
,2
]}

Qiu, Jianxin ^{[2
,3
]}

Rong, Xing ^{[2
,3
]}

Shi, Zhewei ^{[7
]}

Xiao, Jian ^{[6
]}

Shi, Yong ^{[8
]}

Chu, Maoping ^{[1
,2
,3
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Pediat Res Inst, Wenzhou 325027, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 2, Inst Cardiovasc Dev & Translat Med, Childrens Heart Ctr, Wenzhou 325027, Peoples R China

[4] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[5] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, Wenzhou 325027, Peoples R China

[6] Wenzhou Med Univ, Sch Pharm, Pharmacol, Wenzhou, Zhejiang, Peoples R China

[7] Zhuji Peoples Hosp Zhejiang Prov, Dept Cardiol, Shaoxing 311800, Peoples R China

[8] Wenzhou Med Univ, Affiliated Hosp 6, Comprehens Breast Hlth Ctr, Lishui Peoples Hosp,Dept Thyroid & Breast Surg, Lishui 323000, Zhejiang, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2019年 / 67卷

关键词：

Pyroptosis; Cardiovascular diseases; Caspase-1; Caspase-4/5/11; INFLAMMATORY CELL-DEATH; NLRP3; INFLAMMASOME; GASDERMIN D; ISCHEMIA/REPERFUSION INJURY; CARDIOMYOCYTE PYROPTOSIS; MYOCARDIAL-INFARCTION; CASPASE-1; ACTIVATION; PROGRAMMED NECROSIS; BACTERIAL LIGANDS; INHIBITOR;

D O I：

10.1016/j.intimp.2018.12.028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically unique form of programmed cell death compared to others, such as apoptosis and autophagic cell death. More specifically, pyroptosis features gasdermin family-mediated membrane pore formation and subsequent cell lysis, as well as release of pro-inflammatory intracellular contents including IL-1 beta, IL-18 and HMGB1. Mechanistically, pyroptosis is driven by two main signaling pathways - one mediated by caspase-1 and the other by caspase-4/5/11. Recent studies show that pyroptosis is implicated in several cardiovascular diseases. In this review, we summarize recent scientific discoveries of pyroptosis's involvement in atherosclerosis, myocardial infarction, diabetic cardiomyopathy, reperfusion injury and myocarditis. We also organized new and emerging evidence suggesting that pyroptosis signaling pathways may be potential therapeutic targets in cardiovascular diseases.

引用

页码：311 / 318

页数：8

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