Cerebral Ischemia Increases small Ubiquitin-Like Modifier Conjugation within Human penumbral tissue: Radiological-pathological Correlation

被引:12
作者
Bernstock, Joshua D. [1 ,2 ]
Ye, Daniel G. [1 ]
Griffin, Allison [3 ,4 ]
Lee, Yang-ja [1 ]
Lynch, John [3 ]
Latour, Lawrence L. [3 ]
Friedman, Gregory K. [5 ]
Maric, Dragan [6 ]
Hallenbeck, John M. [1 ]
机构
[1] NINDS, Stroke Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
[2] Univ Cambridge, Wellcome Trust Med Res Council Stem Cell Inst, Dept Clin Neurosci, Cambridge, England
[3] NINDS, Sect Stroke Diagnost & Therapeut, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
[4] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA
[5] Univ Alabama Birmingham, Dept Pediat, Div Pediat Hematol & Oncol, Birmingham, AL USA
[6] NINDS, Flow & Imaging Cytometry Core Facil, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
关键词
SUMOylation; ischemic stroke; neuroprotection; magnetic resonance imaging; penumbra; PROTEIN SUMOYLATION; GLUCOSE DEPRIVATION; SUMO; NEUROPROTECTION; THRESHOLDS; ACTIVATION; STROKE; OXYGEN; MICE;
D O I
10.3389/fneur.2017.00738
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Posttranslational modification by small ubiquitin-like modifier (SUMO) regulates myriad physiological processes within cells and has been demonstrated to be highly activated in murine brains after cerebral ischemia. Numerous in vitro and murine in vivo studies have demonstrated that this increased SUMO conjugation is an endogenous neuroprotective stress response that has potential in being leveraged to develop novel therapies for ischemic stroke. However, SUMO activation has not yet been studied in poststroke human brains, presenting a clear limitation in translating experimental successes in murine models to human patients. Accordingly, here, we present a case wherein the brain tissue of a stroke patient (procured shortly after death) was processed by multiplex immunohistochemistry to investigate SUMO activation.
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页数:7
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