Coordination Compounds of Cobalt(II), Nickel(II), and Copper(II) Halides with 2-Methyl-1,2,4-Triazolo[1,5-a]benzimidazole

被引：7

作者：

Dyukova, I. I. ^{[1
,2
]}

Kuz'menko, T. A. ^{[3
]}

Komarov, V. Yu. ^{[1
,2
]}

Sukhikh, T. S. ^{[1
,2
]}

Vorontsova, E. V. ^{[4
]}

Lavrenova, L. G. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Nikolaev Inst Inorgan Chem, Siberian Branch, Novosibirsk 630090, Russia

[2] Novosibirsk Natl State Res Univ, Novosibirsk 630090, Russia

[3] Southern Fed Univ, Inst Phys & Organ Chem, Rostov Na Donu, Russia

[4] Fed Res Ctr Fundamental & Translat Med, Inst Mol Biol & Biophys, Novosibirsk, Russia

来源：

RUSSIAN JOURNAL OF COORDINATION CHEMISTRY | 2018年 / 44卷 / 12期

基金：

俄罗斯基础研究基金会;

关键词：

synthesis; complexes; 3d metals; 2-methyl-1; 2; 4-triazolo[1; 5-a]benzimidazole; X-ray structure analysis; electronic spectroscopy; IR spectroscopy; cytotoxic activity; ANTIMICROBIAL ACTIVITY; COMPLEXES; BENZIMIDAZOLE; 1,2,4-TRIAZOLE; ANTIBACTERIAL; THIABENDAZOLE; PLATINUM(II); IMIDAZOLE; CU(II); CO(II);

D O I：

10.1134/S107032841812014X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New coordination compounds of Co(II), Ni(II), and Cu(II) halides with 2-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L), [Co(L)(2)Cl-2] (Ia), [Ni(L)(2)(H2O)(4)]Cl-2 4H(2)O (II), and [Cu-2(L)(4)(mu-Br)(2)Br-2] (IIIa), are synthesized. The complexes are studied by X-ray structure analysis (CIF files CCDC nos. 1825006-1825008), electronic (diffuse reflectance) spectroscopy, and IR spectroscopy. In compounds Ia, II, and IIIa, ligand L is coordinated to the metal by the N-4 atom of the triazole fragment. The study of the cytotoxic effect of the ligand and synthesized complexes on the Hep-2 line (laryngeal cancer cells) shows a considerably higher activity of the copper(II) complex than that of the ligand.

引用

页码：755 / 764

页数：10

共 35 条

[1]

Akbay A, 2003, ARZNEIMITTELFORSCH, V53, P266

[2] STRUCTURAL AND BIOLOGICAL STUDIES ON BENZIMIDAZOLYL AMINO-ACID COMPLEXES OF DIMETHYLDICHLOROSILANE [J].

AMINABHAVI, TM ;

BIRADAR, NS ;

PATIL, SB ;

HOFFMAN, DE .

INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1986, 125 (03) :125-128

[3]

Anisimova V. A., 2010, KHIM FARM ZH, V44, P7

[4]

[Anonymous], 2017, ICSD WEB VERS 3 7 0

[5] Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases [J].

Bagihalli, Gangadhar B. ;

Avaji, Prakash Gouda ;

Patil, Sangamesh A. ;

Badami, Prema S. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (12) :2639-2649

[6] Imidazole and benzimidazole derivatives as chemotherapeutic agents [J].

Boiani, M ;

González, M .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (04) :409-424

[7]

Bruker AXS Inc, 2004, APEX2 (Version 1.08), SAINT (Version 07.03), SADABS (Version 02.11), SHELXTL (Version 06.12)

[8] Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands [J].

Devereux, Michael ;

Shea, Denis O. ;

Kellett, Andrew ;

McCann, Malachy ;

Walsh, Maureen ;

Egan, Denise ;

Deegan, Carol ;

Kgdziora, Kinga ;

Rosair, Georgina ;

Muelller-Bunz, Helge .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (06) :881-892

[9] OLEX2: a complete structure solution, refinement and analysis program [J].

Dolomanov, Oleg V. ;

Bourhis, Luc J. ;

Gildea, Richard J. ;

Howard, Judith A. K. ;

Puschmann, Horst .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2009, 42 :339-341

[10] Synthesis and potent antimicrobial activity of some novel N-(alkyl)-2-phenyl-1H-benzimidazole-5-carboxamidines [J].

Göker, H ;

Alp, M ;

Yildiz, S .

MOLECULES, 2005, 10 (11) :1377-1386

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