In this work, a simple method is demonstrated for the synthesis of multifunctional core-shell nanoparticles NaYF4:Yb,Er@NaYF4:Yb@NaNdF4:Yb@NaYF4:Yb@PAA (labeled as Er@Y@Nd@Y@PAA or UCNP@PAA), which contain a highly effective 808-nm-to-visible UCNP core and a thin shell of poly(acrylic acid) (PAA) to achieve upconversion bioimaging and pH-sensitive anticancer chemotherapy simultaneously. The core-shell Nd3+-sensitized UCNPs are optimized by varying the shell number, core size, and host lattices. The final optimized Er@Y@Nd@Y nanoparticle composition shows a significantly improved upconversion luminescence intensity, that is, 12.8 times higher than Er@Y@Nd nanoparticles. After coating the nanocomposites with a thin layer of PAA, the resulting UCNP@PAA nanocomposite perform well as a pH-responsive nanocarrier and show clear advantages over UCNP@mSiO(2), which are evidenced by in vitro/in vivo experiments. Histological analysis also reveals that no pathological changes or inflammatory responses occur in the heart, lungs, kidneys, liver, and spleen. In summary, this study presents a major step forward towards a new therapeutic and diagnostic treatment of tumors by using 808-nm excited UCNPs to replace the traditional 980-nm excitation.
机构:
Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Gu, Zhanjun
Yan, Liang
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Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Yan, Liang
Tian, Gan
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机构:
Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R China
Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Tian, Gan
Li, Shoujian
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Li, Shoujian
Chai, Zhifang
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h-index: 0
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Soochow Univ, Sch Radiat Med & Radiat Protect, Suzhou 215123, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chai, Zhifang
Zhao, Yuliang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
机构:
Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Jin, Jiefu
Gu, Yan-Juan
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Gu, Yan-Juan
Man, Cornelia Wing-Yin
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Man, Cornelia Wing-Yin
Cheng, Jinping
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City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Cheng, Jinping
Xu, Zhenhua
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Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Xu, Zhenhua
Zhang, Yue
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h-index: 0
机构:
Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Zhang, Yue
Wang, Huaishan
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Wang, Huaishan
Lee, Vien Hoi-Yi
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Lee, Vien Hoi-Yi
Cheng, Shuk Han
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h-index: 0
机构:
City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Cheng, Shuk Han
Wong, Wing-Tak
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h-index: 0
机构:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
PearL Mat Med Dev Shenzhen Ltd, Shenzhen 518057, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
机构:
Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Gu, Zhanjun
Yan, Liang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Yan, Liang
Tian, Gan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R China
Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Tian, Gan
Li, Shoujian
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Li, Shoujian
Chai, Zhifang
论文数: 0引用数: 0
h-index: 0
机构:
Soochow Univ, Sch Radiat Med & Radiat Protect, Suzhou 215123, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chai, Zhifang
Zhao, Yuliang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R ChinaChinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
机构:
Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Jin, Jiefu
Gu, Yan-Juan
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Gu, Yan-Juan
Man, Cornelia Wing-Yin
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Man, Cornelia Wing-Yin
Cheng, Jinping
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Cheng, Jinping
Xu, Zhenhua
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Xu, Zhenhua
Zhang, Yue
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Zhang, Yue
Wang, Huaishan
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Wang, Huaishan
Lee, Vien Hoi-Yi
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h-index: 0
机构:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Lee, Vien Hoi-Yi
Cheng, Shuk Han
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Cheng, Shuk Han
Wong, Wing-Tak
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
PearL Mat Med Dev Shenzhen Ltd, Shenzhen 518057, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China