Poly(Acrylic Acid) Modification of Nd3+-Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery

被引:243
作者
Liu, Bei [1 ,2 ]
Chen, Yinyin [1 ,2 ]
Li, Chunxia [1 ]
He, Fei [1 ,2 ]
Hou, Zhiyao [1 ]
Huang, Shanshan [1 ]
Zhu, Haomiao [3 ]
Chen, Xueyuan [3 ]
Lin, Jun [1 ]
机构
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350002, Peoples R China
基金
中国国家自然科学基金;
关键词
core-shell nanoparticles; bioimaging; upconversion; drug loading; antitumor chemotherapy; CORE-SHELL NANOSTRUCTURES; NANOPARTICLES; LUMINESCENT; FABRICATION; NANOMATERIALS; NANOCRYSTALS; NANOPROBES; SPHERES; DESIGN; PROBES;
D O I
10.1002/adfm.201501582
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this work, a simple method is demonstrated for the synthesis of multifunctional core-shell nanoparticles NaYF4:Yb,Er@NaYF4:Yb@NaNdF4:Yb@NaYF4:Yb@PAA (labeled as Er@Y@Nd@Y@PAA or UCNP@PAA), which contain a highly effective 808-nm-to-visible UCNP core and a thin shell of poly(acrylic acid) (PAA) to achieve upconversion bioimaging and pH-sensitive anticancer chemotherapy simultaneously. The core-shell Nd3+-sensitized UCNPs are optimized by varying the shell number, core size, and host lattices. The final optimized Er@Y@Nd@Y nanoparticle composition shows a significantly improved upconversion luminescence intensity, that is, 12.8 times higher than Er@Y@Nd nanoparticles. After coating the nanocomposites with a thin layer of PAA, the resulting UCNP@PAA nanocomposite perform well as a pH-responsive nanocarrier and show clear advantages over UCNP@mSiO(2), which are evidenced by in vitro/in vivo experiments. Histological analysis also reveals that no pathological changes or inflammatory responses occur in the heart, lungs, kidneys, liver, and spleen. In summary, this study presents a major step forward towards a new therapeutic and diagnostic treatment of tumors by using 808-nm excited UCNPs to replace the traditional 980-nm excitation.
引用
收藏
页码:4717 / 4729
页数:13
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