Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia

被引：26

作者：

Curtis, David ^{[1
]}

机构：

[1] UCL, UCL Genet Inst, Rockefeller Bldg,21 Univ St, London WC1E 6JJ, England

来源：

PSYCHIATRIC GENETICS | 2016年 / 26卷 / 05期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

association; histone modification; pathway analysis; schizophrenia; GENE;

D O I：

10.1097/YPG.0000000000000132

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Weighted burden pathway analysis was applied to whole exome sequence data for 2045 schizophrenic patients and 2045 controls. Overall, there was a statistically significant excess of pathways with more rare, functional variants in cases than in controls. Among the highest ranked were pathways relating to histone modification, as well as neuron differentiation and membrane and vesicle function. This bolsters the evidence from previous studies that histone modification pathways may be important in the aetiology of schizophrenia.

引用

页码：223 / 227

页数：5

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