Poly Ethoxy Ethyl Glycinamide (PEE-G) Dendrimers: Dendrimers Specifically Designed for Pharmaceutical Applications

被引：6

作者：

Toms, Steven ^{[2
]}

Carnachan, Susan M. ^{[1
]}

Hermans, Ian F. ^{[3
]}

Johnson, Keryn D. ^{[2
]}

Khan, Ashna A. ^{[2
]}

O'Hagan, Suzanne E. ^{[4
]}

Tang, Ching-Wen ^{[3
]}

Rendle, Phillip M. ^{[1
]}

机构：

[1] Victoria Univ Wellington, POB 33 436, Petone 5046, New Zealand

[2] Callaghan Innovat, POB 31 310, Lower Hutt 5040, New Zealand

[3] Malaghan Inst Med Res, POB 7060, Wellington 6242, New Zealand

[4] Univ Queensland, Fac Med & Biomed Sci, Ctr Integrated Preclin Drug Dev, St Lucia Campus, Brisbane, Qld 4072, Australia

来源：

CHEMMEDCHEM | 2016年 / 11卷 / 15期

关键词：

dendrimers; drug discovery; purity; stability; toxicity; POLY(PROPYLENE IMINE) DENDRIMERS; MASS-SPECTROMETRY; PEPTIDE; MALDI; MS;

D O I：

10.1002/cmdc.201600270

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Poly ethoxy ethyl glycinamide (PEE-G) dendrimers have been specifically designed and synthesized with the aim of providing a readily available dendrimer scaffold that can be used to make products that can meet the stringent requirements of pharmaceutical applications. The synthesis has been refined to produce dendrimers that are of high HPLC purity. The suitability of PEE-G dendrimers for their designed use has been verified by subsequent measurements to demonstrate that they are of high stability, high aqueous solubility, low cytotoxicity, low immunogenicity and with low invivo toxicity in an escalating-dose rat study. PEE-G dendrimers therefore provide a useful scaffold for researchers wanting to develop dendrimer-based drug candidates.

引用

页码：1583 / 1586

页数：4

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