IP3 receptor antagonist heparin uncompetitively inhibits [H-3](+)-SKF-10047 binding to sigma receptors

被引：9
|
作者：
Tsao, LI [1 ]
Su, TP [1 ]
机构：
[1] NIA,UNIT PATHOBIOL,MOL NEUROPSYCHIAT SECT,DIV INTRAMURAL RES,NIH,BALTIMORE,MD 21224
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 311卷 / 01期
关键词：
sigma receptor; ryanodine; inositol 1,4,5-trisphosphate;
D O I：
10.1016/0014-2999(96)00533-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Interaction of a receptors with intracellular Ca2+ channel blocker and modulators was examined. Ryanodine and inositol 1,4,5-trisphosphate (IP3) did not inhibit [H-3](+)-N-allylnormetazocine ([H-3](+)-SKF-10047) binding to sigma receptors from either brain microsomal fractions or liver membrane extracts of the rat. However, the IP3 receptor antagonist heparin inhibited [H-3](+)-SKF-10047 to sigma receptors in an uncompetitive manner with a K-i of 93 mu M. These results suggest that sigma receptors may bear some relationship with IP3 receptor associated proteins or channels.
引用
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页码：R1 / R2
页数：2
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