Synthesis of Substituted Pyrazoles via Tandem Cross-Coupling/Electrocyclization of Enol Triflates and Diazoacetates

被引：71

作者：

Babinski, David J. ^{[1
]}

Aguilar, Hector R. ^{[1
]}

Still, Raymond ^{[1
]}

Frantz, Doug E. ^{[1
]}

机构：

[1] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 15期

关键词：

ELECTROCYCLIZATION ENANTIOSELECTIVE SYNTHESIS; DIAZO-COMPOUNDS; CYCLOADDITION; LIGANDS; CYCLIZATION; INHIBITORS; BEHAVIOR;

D O I：

10.1021/jo201042c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-coupling/electrocydization of enol triflates and diazoacetates is presented. The initial scope of this methodology is demonstrated on a range of differentially substituted acyclic and cyclic enol triflates as well as an elaborated set of diazoacetates to provide the corresponding pyrazoles with a high degree of structural complexity.

引用

页码：5915 / 5923

页数：9

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