Preparation and spectroscopic characterization of methoxy poly(ethylene glycol)-grafted water-soluble chitosan

被引：82

作者：

Jeong, Young-Il ^{[1
]}

Kim, Don-Gon ^{[1
]}

Jang, Mi-Kyeong ^{[1
]}

Nah, Jaw-Woon ^{[1
]}

机构：

[1] Sunchon Natl Univ, Coll Engn, Dept Nano Polymer Sci & Engn, BioMed Polymer Lab, Sunchon 540742, Jeonnam, South Korea

来源：

CARBOHYDRATE RESEARCH | 2008年 / 343卷 / 02期

关键词：

water-soluble chitosan; poly(ethylene glycol); aqueous solubility; organic solvent solubility; graft copolymer; EFFICIENT GENE CARRIER; GRAFTED CHITOSAN; COPOLYMERS; PEG; OLIGOSACCHARIDE; NANOPARTICLES; DERIVATIVES; DELIVERY; COMPLEX; CHITIN;

D O I：

10.1016/j.carres.2007.10.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The object of this study was to test the solubility of a methoxy poly(ethylene glycol) (MPEG)-grafted chitosan copolymer in organic solvents and aqueous solution. Water-soluble chitosan with low molecular weight (LMWSC) was used in a PEG-graft copolymerization. The MPEG was conjugated to chitosan using 4-dicyclohexylcarbodimide (DCC), and N-hydroxysuccimide (NHS). Introduction of PEG was confirmed by H-1 and C-13 NMR spectroscopy and FT-IR spectroscopy. The degree of substitution (DS) of MPEG into chitosan was calculated from H-1 NMR data and also by estimating the molecular weight (MW) using gel permeation chromatography (GPC). The DS values obtained from H-1 NMR spectroscopy and GPC were similar, indicating that MPEG-grafted LMWSC was synthesized and properly characterized. Furthermore, the introduction of PEG into chitosan increases the solubility in aqueous solutions over a range of pH values (4.0-11.0) and organic solvents such as DMF, DMSO, ethanol, and acetone. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：282 / 289

页数：8

共 26 条

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