3D printed drug delivery and testing systems - a passing fad or the future?

被引：180

作者：

Lim, Seng Han ^{[1
]}

Kathuria, Himanshu ^{[1
]}

Tan, Justin Jia Yao ^{[1
]}

Kang, Lifeng ^{[2
]}

机构：

[1] Natl Univ Singapore, Dept Pharm, 18 Sci Dr 4,Block S4A,Level 3, Singapore 117543, Singapore

[2] Univ Sydney, Sch Pharm, Pharm & Bank Bldg A15, Sydney, NSW 2006, Australia

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2018年 / 132卷

关键词：

Drug delivery system; Dosage form; 3D printing; Additive manufacturing; Personalised medicine; in vitro drug testing; BIOACTIVE GLASS SCAFFOLDS; ON-A-CHIP; IN-VITRO; CONTROLLED-RELEASE; SILICONE HYDROGEL; EXTENDED-RELEASE; CONTACT-LENSES; TRANSDERMAL DELIVERY; IMMEDIATE-RELEASE; BONE REGENERATION;

D O I：

10.1016/j.addr.2018.05.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The US Food and Drug Administration approval of the first 3D printed tablet in 2015 has ignited growing interest in 3D printing, or additive manufacturing (AM), for drug delivery and testing systems. Beyond just a novel method for rapid prototyping, AM provides key advantages over traditional manufacturing of drug delivery and testing systems. These includes the ability to fabricate complex geometries to achieve variable drug release kinetics; ease of personalising pharmacotherapy for patient and lowering the cost for fabricating personalised dosages. Furthermore, AM allows fabrication of complex and micron-sized tissue scaffolds and models for drug testing systems that closely resemble in vivo conditions. However, there are several limitations such as regulatory concerns that may impede the progression to market. Here, we provide an overview of the advantages of AM drug delivery and testing, as compared to traditional manufacturing techniques. Also, we discuss the key challenges and future directions for AM enabled pharmaceutical applications. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：139 / 168

页数：30

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