The Role of Kisspeptin/GPR54 in the Reproductive System

被引：2

作者：

Papaoiconomou, E. ^{[1
]}

Msaouel, P. ^{[1
]}

Makri, A. ^{[1
]}

Diamanti-Kandarakis, E. ^{[1
]}

Koutsilieris, M. ^{[1
]}

机构：

[1] Univ Athens, Dept Expt Physiol, Sch Med, Athens 11527, Greece

来源：

IN VIVO | 2011年 / 25卷 / 03期

关键词：

Kisspeptin; Kiss-1; GPR54; hypothalamus; sex steroids; gonadotropins; puberty; sexual maturation; sexual differentiation; review; GONADOTROPIN-RELEASING-HORMONE; PROTEIN-COUPLED RECEPTOR; METASTASIS SUPPRESSOR GENE; KISS-1; MESSENGER-RNA; RIBONUCLEIC-ACID EXPRESSION; ESTROGEN POSITIVE FEEDBACK; MONKEY MACACA-MULATTA; LUTEINIZING-HORMONE; FEMALE RAT; HYPOGONADOTROPIC HYPOGONADISM;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The Kiss-1 gene encodes a secreted protein that is proteolytically cleaved to produce a number of structurally related peptides, with high interspecies conservation, globally termed kisspeptins. The original niche for the role of kisspeptin in human physiology is derived from cancer biology, with the loss of Kiss-1 expression being associated with poor prognosis in several malignancies. However, kisspeptin has recently emerged as a fundamental player in the field of reproductive biology. Genetic analysis of large consanguineous pedigrees by two independent groups led to the association of inactivating mutations of GPR54, the receptor which mediates kisspeptin action. with idiopathic hypogonadotropic hypogonadism. In the present paper the most salient aspects of the multifaceted role of kisspeptin in the reproductive system are reviewed, including the association of kisspeptin with the gonadal steroid feedback loop and the triggering of puberty onset.

引用

页码：343 / 354

页数：12

共 98 条

[1] Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats [J].

Adachi, Sachika ;

Yamada, Shunji ;

Takatsu, Yoshihiro ;

Matsui, Hisanori ;

Kinoshita, Mika ;

Takase, Kenji ;

Sugiura, Hitomi ;

Ohtaki, Tetsuya ;

Matsumoto, Hirokazu ;

Uenoyama, Yoshihisa ;

Tsukamura, Hiroko ;

Inoue, Kinji ;

Maeda, Kei-Ichiro .

JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2007, 53 (02) :367-378

[2] GONADOTROPIN-RELEASING HORMONE AND ITS AGONIST INHIBIT TESTICULAR LUTEINIZING-HORMONE RECEPTOR AND STEROIDOGENESIS IN IMMATURE AND ADULT HYPOPHYSECTOMIZED RATS [J].

BAMBINO, TH ;

SCHREIBER, JR ;

HSUEH, AJW .

ENDOCRINOLOGY, 1980, 107 (04) :908-917

[3] Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts [J].

Bilban, M ;

Ghaffari-Tabrizi, N ;

Hintermann, E ;

Bauer, S ;

Molzer, S ;

Zoratti, C ;

Malli, R ;

Sharabi, A ;

Hiden, U ;

Graier, W ;

Knöfler, M ;

Andreae, F ;

Wagner, O ;

Quaranta, V ;

Desoye, G .

JOURNAL OF CELL SCIENCE, 2004, 117 (08) :1319-1328

[4] Kisspeptin synchronizes Preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes [J].

Caraty, A. ;

Smith, J. T. ;

Lomet, D. ;

Ben Saied, S. ;

Morrissey, A. ;

Cognie, J. ;

Doughton, B. ;

Baril, G. ;

Briant, C. ;

Clarke, I. J. .

ENDOCRINOLOGY, 2007, 148 (11) :5258-5267

[5] Effects of galanin-like peptide on luteinizing hormone secretion in the rat:: sexually dimorphic responses and enhanced sensitivity at male puberty [J].

Castellano, J. M. ;

Navarro, V. M. ;

Fernandez-Fernandez, R. ;

Roa, J. ;

Vigo, E. ;

Pineda, R. ;

Steiner, R. A. ;

Aguilar, E. ;

Pinilla, L. ;

Tena-Sempere, M. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2006, 291 (06) :E1281-E1289

[6] Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat [J].

Castellano, J. M. ;

Navarro, V. M. ;

Fernandez-Fernandez, R. ;

Castano, J. P. ;

Malagon, M. M. ;

Aguilar, E. ;

Dieguez, C. ;

Magni, P. ;

Pinilla, L. ;

Tena-Sempere, M. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 257-8 :75-83

[7] Expression of KiSS-1 in rat ovary:: Putative local regulator ovulation? [J].

Castellano, J. M. ;

Gaytan, M. ;

Roa, J. ;

Vigo, E. ;

Navarro, V. M. ;

Bellido, C. ;

Dieguez, C. ;

Aguilar, E. ;

Sanchez-Criado, J. E. ;

Pellicer, A. ;

Pinilla, L. ;

Gaytan, F. ;

Tena-Sempere, M. .

ENDOCRINOLOGY, 2006, 147 (10) :4852-4862

[8] Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism [J].

Cerrato, Felecia ;

Shagoury, Jenna ;

Kralickova, Milena ;

Dwyer, Andrew ;

Falardeau, John ;

Ozata, Metin ;

Van Vliet, Guy ;

Bouloux, Pierre ;

Hall, Janet E. ;

Hayes, Frances J. ;

Pitteloud, Nelly ;

Martin, Kathryn A. ;

Welt, Corrine ;

Seminara, Stephanie B. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2006, 155 :S3-S10

[9] Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge [J].

Clarkson, Jenny ;

de Tassigny, Xavier d'Anglemont ;

Moreno, Adriana Santos ;

Colledge, William H. ;

Herbison, Allan E. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (35) :8691-8697

[10] Postnatal development of kisspeptin neurons in mouse hypothalamus; Sexual dimorphism and projections to gonadotropin-releasing hormone neurons [J].

Clarkson, Jenny ;

Herbison, Allan E. .

ENDOCRINOLOGY, 2006, 147 (12) :5817-5825

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