Histopathology of fluoride-induced hepatotoxicity in rabbits

被引：0
|
作者：
Shashi, A [1 ]
Thapar, SP
机构：
[1] Punjabi Univ, Dept Zool, Patiala 147002, Punjab, India
[2] Dayanand Med Coll & Hosp, Dept Anat, Ludhiana, Punjab, India
来源：
FLUORIDE | 2001年 / 34卷 / 01期
关键词：
albino rabbits; fluoride hepatotoxicity; liver histopathology; sodium fluoride;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The effect of chronic and acute exposure to sodium fluoride (5, 10, 20, and 50 mg/kg body weight/day) for fifteen weeks on hepatic damage in young albino rabbits was evaluated. Histopathological examination revealed increasing degrees of hepatocellular necrosis, degenerative changes, hepatic hyperplasia, extensive vacuolization in hepatocytes, and centrilobular necrosis in the liver of the exposed animals. The central vein and sinusoids of the liver were dilated and engorged with blood and were associated with small areas of haemorrhages, These effects were not observed in the control group.
引用
收藏
页码：34 / 42
页数：9
相关论文
共 50 条
  • [41] PROTECTIVE EFFECT OF MELATONIN AGAINST FLUORIDE-INDUCED OXIDATIVE STRESS IN THE MOUSE OVARY
    Chawla, Sunita L.
    Rao, Mandava V.
    FLUORIDE, 2012, 45 (02) : 125 - 132
  • [42] Histopathology of myocardial damage in experimental fluorosis in rabbits
    Shashi, A
    Thapar, SP
    FLUORIDE, 2001, 34 (01) : 43 - 50
  • [43] An in vivo and in silico probing of the protective potential of betaine against sodium fluoride-induced neurotoxicity
    Owumi, Solomon E.
    Oluwawibe, Bayode J.
    Chimezie, Joseph
    Babalola, Jesutosin J.
    Ogunyemi, Oludare M.
    Gyebi, Gideon A.
    Otunla, Moses T.
    Altayyar, Ahmad
    Arunsi, Uche O.
    Irozuru, Chioma E.
    Owoeye, Olatunde O.
    BMC PHARMACOLOGY & TOXICOLOGY, 2024, 25 (01)
  • [44] SODIUM FLUORIDE-INDUCED CHROMOSOME-ABERRATIONS IN DIFFERENT CELL-CYCLE STAGES
    AARDEMA, MJ
    TSUTSUI, T
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1995, 331 (01) : 171 - 172
  • [45] THE PROTECTIVE EFFECT OF CURCUMIN AGAINST SODIUM FLUORIDE-INDUCED OXIDATIVE STRESS IN RAT HEART
    Nabavi, S. F.
    Nabavi, S. M.
    Ebrahimzadeh, M. A.
    Eslami, Sh.
    Jafari, N.
    Hajizadeh Moghaddam, Akbar
    ARCHIVES OF BIOLOGICAL SCIENCES, 2011, 63 (03) : 563 - 569
  • [46] Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
    Nabavi, Seyed M.
    Nabavi, Seyed F.
    Moghaddam, Akbar H.
    Setzer, William N.
    Mirzaei, Morteza
    ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2012, 84 (04): : 1121 - 1126
  • [47] Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain
    Yan, Nan
    Liu, Yan
    Liu, Shengnan
    Cao, Siqi
    Wang, Fei
    Wang, Zhengdong
    Xi, Shuhua
    MOLECULAR NEUROBIOLOGY, 2016, 53 (07) : 4449 - 4460
  • [48] Fluoride-Induced Expression of Neuroinflammatory Markers and Neurophysiological Regulation in the Brain of Wistar Rat Model
    Yugandhar P. Reddy
    Santosh Tiwari
    Lomas K. Tomar
    Nalini Desai
    Varun Kumar Sharma
    Biological Trace Element Research, 2021, 199 : 2621 - 2626
  • [49] Fluoride-Induced Expression of Neuroinflammatory Markers and Neurophysiological Regulation in the Brain of Wistar Rat Model
    Reddy, Yugandhar P.
    Tiwari, Santosh
    Tomar, Lomas K.
    Desai, Nalini
    Sharma, Varun Kumar
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2021, 199 (07) : 2621 - 2626
  • [50] Effect of oxidative stress on fluoride-induced apoptosis in primary cultured Sertoli cells of rats
    Yang, Yang
    Huang, Hui
    Ba, Yue
    Cheng, Xue-Min
    Cui, Liu-Xin
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, 2015, 25 (01) : 1 - 9
12345