Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation

被引：20

作者：

Iandolo, Donata ^{[1
]}

Sheard, Jonathan ^{[2
,3
]}

Levy, Galit Karavitas ^{[4
]}

Pitsalidis, Charalampos ^{[1
]}

Tan, Ellasia ^{[5
,6
]}

Dennis, Anthony ^{[4
]}

Kim, Ji-Seon ^{[5
,6
]}

Markaki, Athina E. ^{[4
]}

Widera, Darius ^{[2
]}

Owens, Roisin M. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England

[2] Univ Reading, Sch Pharm, Cell Biol & Regenerat Med Grp, Whiteknights Campus, Reading RG6 6AP, Berks, England

[3] Sheard BioTech Ltd, Wenlock Rd, London N1 7GU, England

[4] Univ Cambridge, Dept Engn, Trumpington St, Cambridge CB2 1PZ, England

[5] Imperial Coll London, Dept Phys, London SW7 2B, England

[6] Imperial Coll London, Ctr Plast Elect, London SW7 2B, England

来源：

MRS COMMUNICATIONS | 2020年 / 10卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

COLLAGEN SCAFFOLDS; TISSUE SCAFFOLDS; MATRIX STIFFNESS; BONE; RAMAN; PROLIFERATION; CONDUCTIVITY; TEMPERATURE;

D O I：

10.1557/mrc.2020.10

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds' electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.

引用

页码：179 / 187

页数：9

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