Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

被引：35

作者：

Xu, Kuo ^{[1
]}

Yuan, Xiao-Long ^{[1
]}

Li, Chen ^{[2
,3
]}

Li, Xiao-Dong ^{[2
,3
]}

机构：

[1] Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Shandong, Peoples R China

[2] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China

[3] Ludong Univ, Key Lab Marine Biotechnol, Univ Shandong, Sch Life Sci, Yantai 264025, Peoples R China

来源：

MARINE DRUGS | 2020年 / 18卷 / 01期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Aspergillus; metabolite; marine; alkaloid; biological activity; SECONDARY METABOLITES; ABSOLUTE-CONFIGURATION; BIOLOGICAL-ACTIVITIES; INDOLE-DITERPENOIDS; OXINDOLE ALKALOIDS; NATURAL-PRODUCTS; FUNGUS; DERIVATIVES; PEPTIDES; DIKETOPIPERAZINES;

D O I：

10.3390/md18010054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived Aspergillus species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived Aspergillus species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.

引用

页数：22

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