Recent Advances in Palladium-Catalyzed Cascade Cyclizations

被引：241

作者：

Vlaar, Tjostil ^{[1
]}

Ruijter, Eelco ^{[1
]}

Orru, Romano V. A. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, NL-1081 HV Amsterdam, Netherlands

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 06期

关键词：

cascade reactions; catalysis; cyclization; multicomponent reactions; palladium; tandem reactions; ANION CAPTURE PROCESSES; RING EXPANSION REACTION; SEQUENTIAL HOMOBIMETALLIC CATALYSIS; EMPLOYING CARBON-MONOXIDE; N-ANNULATION ROUTE; ONE-POT SYNTHESIS; 2,3-DISUBSTITUTED INDOLES; PROPARGYLIC CARBONATES; NITROGEN-HETEROCYCLES; COUPLING REACTIONS;

D O I：

10.1002/adsc.201000979

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The importance of palladium-catalyzed cross coupling reactions in contemporary organic synthesis is undisputed and underlined by the Nobel Prize for Chemistry in 2010. In addition to the highly efficient cross coupling reactions for single C-C bond construction, palladium-catalyzed cascade processes involving multiple bond formations have emerged in recent years as valuable tools for the rapid synthesis of complex molecular scaffolds. This review presents an overview of the most relevant developments in this field, with a focus on the generation of diverse poly-and heterocyclic scaffolds. The generally well understood reactivity of palladium has allowed the discovery of many intriguing novel cascade processes, and the creativity of the synthetic community will undoubtedly lead to many more discoveries in the future.

引用

页码：809 / 841

页数：33

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