OBESITY Obesity and cardiometabolic disease - more than meets the eye

被引：15

作者：

Aslibekyan, Stella ^{[1
]}

Garvey, W. Timothy ^{[2
,3
]}

机构：

[1] Univ Alabama Birmingham, Dept Epidemiol, 1675 Univ Blvd, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Nutr Sci, 1675 Univ Blvd, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Birmingham VA Med Ctr, 1675 Univ Blvd, Birmingham, AL 35294 USA

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2017年 / 13卷 / 10期

关键词：

SYSTEM; RISK;

D O I：

10.1038/nrendo.2017.112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Whether obesity is a cause of type 2 diabetes mellitus and coronary heart disease or a shared risk factor has been an enduring subject of debate. Lyall and colleagues have used Mendelian randomization to conclude that there is a causal relationship between obesity and cardiometabolic disease. However, the analyses fail key inherent assumptions. The article does not negate a large body of data indicating that insulin resistance is the primary mechanism driving the progression of cardiometabolic disease.

引用

页码：566 / 567

页数：2

共 9 条

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