Metal-phenolic network coatings for engineering bioactive interfaces

The surface modification of biomaterials is crucial for constructing bioactive interfaces capable of interacting with specific biomolecules, controlling cell behavior and regulating biological processes. Because of their excellent biocompatibility, facile preparation, pH-responsiveness and universal adhesion, surface coatings made from metal-phenolic network (MPN) have attracted extensive attention for handling interfacial properties and designing biomaterials in recent years. Different methods and technologies for assembling MPN coatings are summarized and compared in this paper, followed by highlighting the advantages of MPN coatings as bioactive interfaces for controlling biological process at the molecular, cellular, and tissue levels. Current challenges and prospects of MPN coatings for biomedical applications are also discussed.