Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome

被引：53

作者：

Zheng, Yingxia ^{[1
]}

Wang, Zhihao ^{[1
]}

Deng, Lin ^{[1
]}

Zhang, Guanghui ^{[1
]}

Yuan, Xiangliang ^{[1
]}

Huang, Liya ^{[2
]}

Xu, Weiping ^{[3
]}

Shen, Lisong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Lab Med, Shanghai 200092, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Gerontol, Shanghai 200092, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Internal Cardiol, Shanghai 200092, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2015年 / 157卷 / 01期

基金：

中国国家自然科学基金;

关键词：

STAT3; STAT5; Acute coronary syndrome; Th17; cells; Treg cells; REGULATORY T-CELLS; FOXP3; EXPRESSION; CARDIOVASCULAR-DISEASE; TH17/TREG IMBALANCE; INHIBITION; INTERLEUKIN-17; INFLAMMATION; GENERATION; PLASTICITY; MECHANISM;

D O I：

10.1016/j.clim.2014.12.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The signal transducer and activator of transcription (STAT) activity plays an important role in the differentiation and imbalance of Th17 and Treg cells in acute coronary syndrome (ACS) patients. We determined that the basal STAT3 phosphorylation level was significantly increased and exhibited a positive relationship with Th17 cells but was negatively correlated with Treg cells in ACS patients. Opposite effects were observed for STAT5 activity. Using the pharmaceutical inhibitor TG101348 or knockdown of STAT3 reduced the number of Th17 cells while promoting the number and function of Treg cells via the Janus kinase2 (JAK2)/STAT3 pathway in ACS patients. Significantly more STAT5 bound to the Foxp3 locus when STAT3 was knocked down, and overexpression of STAT5 led to an increased number of Treg cells but a decreased number of Th17 cells in ACS patients. Our findings demonstrate that modulation of STAT3/STAT5 activity rectifies the imbalance of Th17/Treg cells in ACS patients. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：65 / 77

页数：13

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