Association of silk sericin and platelet lysate: Premises for the formulation of wound healing active medications

Silk sericin (SS), a globular and water-soluble protein, showed to in vitro sustain the proliferation of different mammalian cell lines, and to in vitro protect them from the oxidative stress because of its free-radical-scavenging activity. Also, platelet-derived products, such as platelet gel, platelet rich plasma or platelet lysate (PL) are used in cell cultures as a serum substitute due to their great content of growth factors. In the clinical practice, both SS and PL were employed for various reparative treatments and showed to sustain the wound repair process regulating fibroblast recruitment, migration, proliferation and differentiation. For these reasons, the combination of PL and SS could lead to effective and innovative products, either for the ex vivo cell expansion, or for the production of active wound healing advanced medications. (C) 2018 Elsevier B.V. All rights reserved.