Economic Assessment of Cardiac Resynchronization Therapy

被引:14
作者
Callejo, Daniel [1 ]
Guerra, Mercedes [1 ]
Hernandez-Madrid, Antonio [2 ]
Blasco, Juan A. [1 ]
机构
[1] Agencia Lain Entralgo Comunidad Madrid, UETS, Madrid, Spain
[2] Hosp Ramon & Cajal, Serv Cardiol, Unidad Arritmias, E-28034 Madrid, Spain
来源
REVISTA ESPANOLA DE CARDIOLOGIA | 2010年 / 63卷 / 11期
关键词
Pacemakers; Heart failure; Cardiac; resynchronization; Cost-benefit analysis; Electrophysiology; Defibrillator; CHRONIC HEART-FAILURE; COST-EFFECTIVENESS; GUIDELINES; DIAGNOSIS;
D O I
10.1016/S0300-8932(10)70293-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction and objectives. Cardiac resynchronization devices have been shown to be effective in treating heart failure. They reduce overall mortality, heart failure mortality and hospitalizations due to heart failure. The aim of this study was to compare the cost-effectiveness of cardiac resynchronization therapy (CRT) with that of optimal drug therapy (ODT) by carrying out an economic assessment in the Spanish healthcare setting. Methods. An existing model was adapted for use in the Spanish healthcare setting. The effectiveness of cardiac resynchronization therapy was determined from published systematic reviews. The costs of the various interventions were determined using a range of Spanish data sources. The model adopted the perspective of the public health system and the time horizon considered was the remainder of the patient's life. The outcome variables were life-years gained and quality-adjusted life-years (QALYs) gained. Results. Overall, ODT, CRT and CRT with a defibrillator resulted in gains of 2.11, 2.8 and 3.19 QALYs, respectively, at a cost of ((sic) 11,722, (sic) 31,629 and (sic) 52,592, respectively. Consequently, each QALY gained with CRT relative to ODT involved the consumption of 28,612 of additional resources. Similarly, the use of CRT with a defibrillator cost an additional (sic) 53,547 per QALY relative to CRT without a defibrillator. Conclusions. The use of CRT without a defibrillator could be a cost-effective alternative to ODT for treating heart failure in a carefully selected group of patients. The study results were sensitive to uncertainties in many of the variables used in the model.
引用
收藏
页码:1235 / 1243
页数:9
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