Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

被引：75
作者：
Chen, Miaomiao [1 ,2 ,3 ]
Lai, Xingning [1 ,4 ]
Wang, Xifeng [5 ]
Ying, Jun [1 ,2 ]
Zhang, Lieliang [1 ,2 ]
Zhou, Bin [1 ,2 ]
Liu, Xing [1 ,2 ]
Zhang, Jing [1 ,2 ]
Wei, Gen [1 ,2 ]
Hua, Fuzhou [1 ,2 ]
机构：
[1] Nanchang Univ, Dept Anesthesiol, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China
[2] Key Lab Anesthesiol Jiangxi Prov, Nanchang, Jiangxi, Peoples R China
[3] Nanchang Univ, Clin Med Coll 1, Nanchang, Jiangxi, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu, Peoples R China
[5] Nanchang Univ, Dept Anesthesiol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2021年 / 14卷
基金：
中国国家自然科学基金;
关键词：
lncRNA; circRNA; microglia; astrocyte; neurological diseases; TRAUMATIC BRAIN-INJURY; SPINAL-CORD-INJURY; CEREBRAL-ISCHEMIA; INFLAMMATORY RESPONSE; REPERFUSION INJURY; ACTIVATION; STROKE; NEUROINFLAMMATION; POLARIZATION; MODULATION;
D O I：
10.3389/fnmol.2021.745066
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype. Activated microglia and activated astrocytes can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), two groups of non-coding RNAs (ncRNAs), can function as competing endogenous RNAs (ceRNAs) to impair the microRNA (miRNA) inhibition on targeted messenger RNAs (mRNAs). LncRNAs and circRNAs are involved in various neurological disorders. In this review, we summarized that lncRNAs and circRNAs participate in microglia dysfunction, astrocyte dysfunction, neuron damage, and inflammation. Thereby, lncRNAs and circRNAs can positively or negatively regulate neurological diseases, including spinal cord injury (SCI), traumatic brain injury (TBI), ischemia-reperfusion injury (IRI), stroke, neuropathic pain, epilepsy, Parkinson's disease (PD), multiple sclerosis (MS), and Alzheimer's disease (AD). Besides, we also found a lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte mediated neurological diseases. Through this review, we hope to cast light on the regulatory mechanisms of lncRNAs and circRNAs in microglia and astrocyte mediated neurological diseases and provide new insights for neurological disease treatment.
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页数：18
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