Structural basis for reduced activity of 1-aminocyclopropane-1-carboxylate synthase affected by a mutation linked to andromonoecy

被引：6
作者：
Schaerer, Martin A. [1 ]
Eliot, Andrew C. [2 ]
Gruetter, Markus G. [3 ]
Capitani, Guido [1 ,3 ]
机构：
[1] Paul Scherrer Inst, CH-5232 Villigen, Switzerland
[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[3] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland
来源：
FEBS LETTERS | 2011年 / 585卷 / 01期
关键词：
1-aminocyclopropane-1-carboxylate synthase; Pyridoxal 5 '-phosphate; Andromonoecy; Ethylene signalling; Protein crystallography; Comparative modelling; ACC SYNTHASE; WILD-TYPE; ETHYLENE; COMPLEX; AMINOETHOXYVINYLGLYCINE; BIOSYNTHESIS; SPECIFICITY; ENZYME; LEADS;
D O I：
10.1016/j.febslet.2010.11.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1-aminocyclopropane-1-carboxylate synthase (ACS) is a key enzyme in the biosynthesis of the plant hormone ethylene. Recently, a new biological role for ACS has been found in Cucumis melo where a single point mutation (A57V) of one isoform of the enzyme, causing reduced activity, results in andromonoecious plants. We present here a straightforward structural basis for the reduced activity of the A57V mutant, based on our work on Malus domestica ACS, including a new structure of the unliganded apple enzyme at 1.35 angstrom resolution. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：111 / 114
页数：4
相关论文
共 50 条
  • [41] Delay of flower senescence by bacterial endophytes expressing 1-aminocyclopropane-1-carboxylate deaminase
    Ali, S.
    Charles, T. C.
    Glick, B. R.
    JOURNAL OF APPLIED MICROBIOLOGY, 2012, 113 (05) : 1139 - 1144
  • [42] Prevalence of 1-aminocyclopropane-1-carboxylate deaminase in Rhizobium spp.
    Ma, WB
    Sebestianova, SB
    Sebestian, J
    Burd, GI
    Guinel, FC
    Glick, BR
    ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2003, 83 (03): : 285 - 291
  • [43] 1-aminocyclopropane-1-carboxylate synthase of Penicillium citrinum:: Primary structure and expression in Escherichia coli and Saccharomyces cerevisiae
    Kakuta, Y
    Igarashi, T
    Murakami, T
    Ito, H
    Matsui, H
    Honma, M
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2001, 65 (07) : 1511 - 1518
  • [44] Null Mutation of the MdACS3 Gene, Coding for a Ripening-Specific 1-Aminocyclopropane-1-Carboxylate Synthase, Leads to Long Shelf Life in Apple Fruit
    Wang, Aide
    Yamakake, Junko
    Kudo, Hisayuki
    Wakasa, Yuhya
    Hatsuyama, Yoshimichi
    Igarashi, Megumi
    Kasai, Atsushi
    Li, Tianzhong
    Harada, Takeo
    PLANT PHYSIOLOGY, 2009, 151 (01) : 391 - 399
  • [45] Molecular cloning and expression analysis of an 1-aminocyclopropane-1-carboxylate synthase gene from Oncidium Gower Ramsey
    Shi, Le-Song
    Liu, Jin-Ping
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 469 (02) : 203 - 209
  • [46] Identification of two chilling-regulated 1-aminocyclopropane-1-carboxylate synthase genes from citrus (Citrus sinensis Osbeck) fruit
    Wong, WS
    Ning, W
    Xu, PL
    Kung, SD
    Yang, SF
    Li, N
    PLANT MOLECULAR BIOLOGY, 1999, 41 (05) : 587 - 600
  • [47] Ethylene and 1-Aminocyclopropane-1-carboxylate (ACC) in Plant-Bacterial Interactions
    Nascimento, Francisco X.
    Rossi, Marcio J.
    Glick, Bernard R.
    FRONTIERS IN PLANT SCIENCE, 2018, 9
  • [48] Ethylene production and 1-aminocyclopropane-1-carboxylate (ACC) synthase and ACC oxidase gene expression in apple fruit are affected by 9,10-ketol-octadecadienoic acid (KODA)
    Kondo, S.
    Tomiyama, H.
    Kittikorn, M.
    Okawa, K.
    Ohara, H.
    Yokoyama, M.
    Ifuku, O.
    Saito, T.
    Ban, Y.
    Tatsuki, M.
    Moriguchi, T.
    Murata, A.
    Watanabe, N.
    POSTHARVEST BIOLOGY AND TECHNOLOGY, 2012, 72 : 20 - 26
  • [49] A COMPARISON OF 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE INVITRO TRANSLATION PRODUCT AND INVIVO-LABELED PROTEIN IN RIPENING TOMATOES
    EDELMAN, L
    KENDE, H
    PLANTA, 1990, 182 (04) : 635 - 638
  • [50] Functional investigation of two 1-aminocyclopropane-1-carboxylate (ACC) synthase-like genes in the moss Physcomitrella patens
    Lifang Sun
    Hui Dong
    Yuanyuan Nasrullah
    Ning Ning Mei
    Plant Cell Reports, 2016, 35 : 817 - 830
12345