Dendritic cell defects in the colorectal cancer

被引：92

作者：

Legitimo, Annalisa ^{[1
]}

Consolini, Rita ^{[1
]}

Failli, Alessandra ^{[1
]}

Orsini, Giulia ^{[1
]}

Spisni, Roberto ^{[2
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[2] Univ Pisa, Dept Surg Med Mol & Crit Area Pathol, Pisa, Italy

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2014年 / 10卷 / 11期

关键词：

colorectal cancer; dendritic cells; immunoescape; immune response; tumor microenvironment; CRC; Colorectal cancer; GM-CSF; granulocyte macrophage colony stimulating factor; IL; interleukin; IFN; interferon; TNF; tumor necrosis factor; TGF; transforming growth factor; VEGF; vascular endothelial growth factor; DCs; mDCs; myeloid dendritic cells; pDCs; plasmacytoid dendritic cells; DCregs; regulatory DCs; TIDCs; tumor-infiltrating DCs; NK; natural killer; MHC; major histocompatibility complex; PAMP; pathogen-associated molecular pattern; PRRs; pattern recognition receptors; TLR; toll-like receptor; Th; T helper; HNSCC; head and neck squamous cell carcinoma; APC; antigen presenting cells; TDLNs; draining lymph nodes; MDSCs; myeloid-derived suppressor cells; HMGB; high mobility group box; CTLA-4; anticytotoxic T-lymphocyte antigen 4; PD-1; programmed death 1; ENDOTHELIAL GROWTH-FACTOR; CD8(+) T-CELLS; BOX; HMGB1; TUMOR MICROENVIRONMENT; SUPPRESSOR-CELLS; MESSENGER-RNA; MYELOID CELLS; STEADY-STATE; MATURATION; GENERATION;

D O I：

10.4161/hv.29857

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Colorectal cancer (CRC) results from the accumulation of both genetic and epigenetic alterations of the genome. However, also the formation of an inflammatory milieu plays a pivotal role in tumor development and progression. Dendritic cells (DCs) play a relevant role in tumor by exerting differential pro-tumorigenic and anti-tumorigenic functions, depending on the local milieu. Quantitative and functional impairments of DCs have been widely observed in several types of cancer, including CRC, representing a tumor-escape mechanism employed by cancer cells to elude host immunosurveillance.Understanding the interactions between DCs and tumors is important for comprehending the mechanisms of tumor immune surveillance and escape, and provides novel approaches to therapy of cancer. This review summarizes updated information on the role of the DCs in colon cancer development and/or progression.

引用

页码：3224 / 3235

页数：12

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